background: vaccines capable of controlling tumor virus based infections are found difficult to develop due to the consistence latent infection in the host. dna vaccines are attractive tools for the development of hpv vaccines and inducing antigen-specific immunity owing to the stability, simplicity of delivery, safety and cost effectiveness. however, there is a need to increase their potency b...

Background: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB). Bacille Calmette-Guerin (BCG) vaccine, is not effective in adults, therefore, many efforts have been made to produce an effective adult TB vaccine. The aim of this study was to develop a new tuberculosis DNA vaccine candidate encoding a recombinant HspX-PPE44-EsxV fusion antigen of M. tuberculosis. Methods: ...

background hypervariability of hcv proteins is an important obstacle to design an efficient vaccine for hcv infection. multi-epitope vaccines containing conserved epitopes of the virus could be a promising approach for protection against hcv. objectives cellular and humoral immune responses against multi-epitope dna and peptide vaccines were evaluated in balb/c mice. materials and methods in th...

Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's population is infected with tuberculosis and the current BCG vaccine has low efficiency; hence, it is necessary to develop a new vaccine against TB. The aim of the current study was to evaluate the efficiency of a novel DNA vaccine encoding Mtb32C-HBHA antigen in inducing specific immune responses...

Objective(s): Infection with tuberculosis (TB) is regarded as a major health issue. Due to the emergence of antibiotic resistance during TB treatment, prevention via vaccination is one of the most effective ways of controlling the infection. DNA vaccines are developed at a greater pace due to their ability in generating a long-lasting immune response, higher safety com...

Objective(s): Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogen, causes 1.5 million deaths globally. Bacilli Calmette-Guérin (BCG) is commonly administered to protect people against M. tuberculosis infection; however, there are some obstacles with this first-generation vaccine. DNA vaccines, the third generation vaccines, can induce cellular immun...

objective: the global hiv epidemic continues to expand and exceeding previous predictions. an effective vaccine represents the best hope to curtail the hiv epidemic. dna vaccines induce humoral and cellular responses and mimic live vaccines without their pathogenic potential. the importance of cd8+ ctl responses in controlling hiv and siv viremia has led to production of a series of vaccine can...

conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...

the prevalence of hepatitis c virus (hcv) is approximately 3% around the world. this virus causes chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. the effectiveness of interferon-α and ribavirin therapy is about 50% and is associated with significant toxicity and cost. hence, generating new vaccines or drugs is an obligation. however, there is no vaccine available for clinical u...