When combinatorial antibody libraries are rendered infectious for eukaryotic cells, the integrated antibody genotype and cellular phenotype become permanently linked and each cell becomes a selection system unto itself. These systems should be ideal for the identification of proteins and pathways that regulate differentiation so long as selection systems can be devised. Here we use a selection ...

– In recent years, the gay man/heterosexual woman couple configuration has become a genre unto itself in mediated popular culture, resulting in unprecedented mainstream visibility for gay men. Major mainstream films, such as My Best Friend’s Wedding, Object of My Affection, and The Next Best Thing, showcase this combination as their centerpiece, as does the highly rated prime-time network situa...

Sphere close packed (SCP) lattice arrangements of points are well-suited for formulating symmetric quadrature rules on simplexes, as they are symmetric under affine transformations of the simplex unto itself in 2D and 3D. As a result, SCP lattice arrangements have been utilized to formulate symmetric quadrature rules with Np = 1, 4, 10, 20, 35, and 56 points on the 3-simplex (Shunn andHam, 2012...

Knowledge representation (KR) has traditionally been thought of as the heart of artificial intelligence. Anyone who has ever built an expert system, a natural language system-almost any AI system at all-has had to tackle the problem of representing its knowledge of the world. Despite it ubiquity, for most of AI’s history KR has been a backstage activity. But in the 1980’s it emerged as a field ...

The etiology of drug abuse/dependence is a complex interplay of psychosocial and biological factors. These factors include socioeconomic status, education, drug availability, peer pressure, childhood and adult comorbid psychiatric disorders, and specific mutant genes. The emphasis of this chapter is on the role that genetic factors play in an individual's vulnerability to drug abuse/dependence,...