The aim of this study was to investigate the pathological changes in a rat model of Alzheimer's disease (AD) and the effect of donepezil hydrochloride (HCl) treatment. The rat model of AD was established by the bilateral injection of amyloid β₁₋₄₀ (Aβ₁₋₄₀) into the hippocampus. Changes in spatial learning and memory functions were examined using the Morris water maze test and changes in catalas...

characterized by a deficiency in central cholinergic neurotransmission. Donepezil hydrochloride, (¡3⁄4)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6dimethoxyindan-1-one monohydrochloride, is a reversible acetylcholinesterase inhibitor that has been reported to have a high potency and selectivity for centrally active cholinesterase. Matsui and co-workers reported that the concentration and area under ...

OBJECTIVE Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, in such patients in a randomized, double-blind, placebo-controlled exploratory phase 2 trial. METHODS One-hundred forty patients with DLB, recruited from 48 specialty centers in Japan, were randomly assigned to receive placebo or 3, 5, ...

The purpose of this research was to prepare and evaluate a non-bitter donepezil hydrochloride (DH) orally disintegrating tablet (ODT) for enhanced patient compliance. Taste masking was done by preparing microspheres with different ratios of drug and Eudragit EPO using spray drying method. The entrapment of the drug into microspheres was confirmed by scanning electron microscope (SEM) and X-ray ...

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mi...