OBJECTIVE: To establish an experimental model of extracorporeally perfused non-pregnant swine uteri for the study of uterine contractility, peristalsis and transport mechanisms through the female genital tract using an intrauterine double-chip microcatheter. In order to validate the model described biochemical parameters were assessed during the whole perfusion time. METHODS: An extracorporeal ...

Presenter: Britney Harris MD | West Virginia University, Morgantown Background: Minimally invasive pancreaticoduodenectomy (MIPD) has emerged as a promising alternative to open pancreaticoduodenectomy. However, the learning curve associated with mastering this complex operation is significant hurdle for new programs and widespread implementation. Novel training modalities that realistically sim...

many empirical papers have applied a semi-parametric two-stage procedure named tobit model to investigate the sources of inefficiency in different industries over the last two decades. using this approach in small samples has recently been criticized for a possible bias in its results. in very recent papers simar and wilson (2007) have tackled this problem by suggesting an alternative bootstrap...

OBJECTIVES Coronary venous retroinfusion (CVR) has been used experimentally in large animals for selective drug delivery into ischaemic myocardium. It would be an advantage if CVR could also be used in isolated perfused rat heart models. The aim of the present paper is to develop a regional ischaemic model in the isolated perfused rat heart combined with CVR. METHOD Pharmacokinetic study: The...

Information about the muscarinic receptor subtype(s) mediating pulmonary circulatory vasodilator responses to acetylcholine (ACh) is limited. The aim of this study was to pharmacologically characterize the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a pulmonary hypertension model. Vasodilation of rabbit isolated buffer-perfused lungs in which pulmonary hypertensio...

The number of perfused capillaries in skeletal muscle varies with muscle activation. With increasing activation, muscle fibers are recruited as motor units consisting of widely dispersed fibers, whereas capillaries are recruited as groups called microvascular units (MVUs) that supply several adjacent fibers. In this study, a theoretical model was used to examine the consequences of this spatial...

Metabolic studies using the in vitro non-recirculating blood-perfused isolated heart model require large volumes of blood. The present study was designed to determine whether heterologous pig blood collected from a slaughterhouse can be used as perfusate for isolated pig hearts perfused under aerobic and constant reduced flow conditions. Eight isolated working pig hearts perfused for 90 min at ...