A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine...

Abstract Green analytical procedures are gaining popularity in the pharmaceutical research area as a way to reduce environmental impact and improve analyst health safety. The current work presents green sensitive electrochemical carbon paste electrode that has been chemically modified with zirconium dioxide multi-walled nanotubes for estimation of pyridoxine HCl (PYR) doxylamine succinate (DOX)...

Simultaneous estimation of three component tablets containing Doxylamine succinate (DOX), Pyridoxine hydrochloride (PYR) and Folic acid (FA) was carried out by UV spectrophotometric assisted chemometric methods. Four chemometric methods i.e. classical least square (CLS), inverse least square (ILS), principal component regression (PCR) and partial least squares (PLS) were applied to simultaneous...

OBJECTIVE To evaluate whether ondansetron or the combination of doxylamine and pyridoxine was superior for the treatment of nausea and vomiting of pregnancy. METHODS This was a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy were assigned to 4 mg of ondansetron plus a placebo tablet or 25 mg pyridoxine plus 12.5 mg of doxylamine for 5 days. The ...

In this study, we try to implant chaotic features into the learning algorithm of self-organizing map. We call this concept as Chaotic SOM (CHAOSOM). As a first step to realize CHAOSOM, we consider the case that learning rate and neighboring coefficient of SOM are refreshed by chaotic pulses generated by the Hodgkin-Huxley equation. We apply the CHAOSOM to solve a traveling salesman problem and ...

BACKGROUND Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed. We re-analysed the findings of a previously reported superiority trial of doxylamine-pyridoxine for the treatment of nausea and vomiting during pregnancy using the clinical study report obtained from Health Canada. METHODS AND FINDINGS We re-analyse...

BACKGROUND Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries. OBJECTIVES To evaluate the efficacy and safety of a simple bi-daily treatment regimen with the combination of pyridoxine (50 mg twice daily) and doxylamine (25-50 mg) as an alternative treatment for NVP. ...

Testing is an important task of the software development process. It gives assurance of many things, for example that the software executes correctly or that its performance is within acceptable limits – it gives assurance of the quality for the software. Despite this fact, testing is the task that often gets down prioritized because of budget constraints or time shortage. Often this depends on...

Attention has recently focused on the possible teratogenic effects of the combination antiemetic doxylamine succinate, dicyclomine hydrochloride and pyridoxine hydrochloride (Debendox/Bendectin) prescribed to pregnant women. The InterRegional Epidemiological Study of Childhood Cancer (IRESCC), a case-control investigation has analysed data derived from interview reports and medical records of 5...