Doppel (Dpl) is a PrP-like protein, coded by a gene named PRND, located near the PRNP (prion proten coding gene) locus. Human Dpl is a 179-amino acid protein showing approximately 25% sequence identity with the carboxyproximal two thirds of the human cellular prion protein (PrPC). A comparison of the structures of Dpl and PrP(C) reveals similarities in the secondary structure and topology. Apar...

 Abstract Background: There are a large number of patients with penetrating abdominal trauma who have normal vital signs and negative abdominal examination when referred to trauma centers. Agreat deal of controversy exists between authorities about screening these patients for emergency explorative laparotomy. Many references have reported more than 90% sensitivity for DPL as a diagnostic metho...

The signature extraction process is based on a comparison with a common function repository. By eliminatin functions appearing in the common function repository from the signature candidate list, P-DPL can minimize the risk of false-positive detection errors. To minimize false-positive rates for P-DPL proposes intelligent candidate selection using entropy score to generate signatures. Evaluatio...

Intraperitoneal sepsis is difficult to diagnose in thermally injured patients. We reviewed the use of diagnostic peritoneal lavage (DPL) in burn patients suspected of having intraperitoneal infection. Seventeen patients were identified in whom celiotomy, autopsy, or complete recovery could be used to validate the lavage results. A lavage was considered positive if there were greater than 500 wh...

PrP knockout mice in which only the open reading frame was disrupted ('Zürich I') remained healthy. However, more extensive deletions resulted in ataxia, Purkinje cell loss and ectopic expression in brain of Doppel (Dpl), encoded by the downstream gene, PRND: A new PrP knockout line, 'Zürich II', with a 2.9 kb PRNP: deletion, developed this phenotype at approximately 10 months (50% morbidity). ...

Doppel (Dpl) is a paralogue of the mammalian Prion (PrP) protein. It is abundant in testis and, unlike PrP, it is expressed at low levels in the adult central nervous system (CNS). Besides, Dpl overexpression correlates with some prion-disease pathological features, such as ataxia and death of cerebellar neurons. Recently, ectopic expression of doppel was found in two different tumor types, spe...

Doppel protein (Dpl) is a paralog of the cellular form of the prion protein (PrP(C)), together sharing common structural and biochemical properties. Unlike PrP(C), which is abundantly expressed throughout the central nervous system (CNS), Dpl protein expression is not detectable in the CNS. Interestingly, its ectopic expression in the brain elicits neurodegeneration in transgenic mice. Here, by...

wheat stubble (ws) and date palm leaf (dpl) were inoculated with pleurotus florida where in a completely randomized experiment, seven treatments including: 1)untreated ws (utws); 2) fungal treated ws at mycelial running stage (mtws); 3) fungal treated ws after first harvesting of mushroom (ftws1); 4) fungal treated ws after second harvesting of mushroom (ftws2); 5) untreated dpl (udpl); 6) fung...

In [PP93] we described a transformational approach to realizing architecture independent parallel execution of a high-level parallel language. Detailed in that document is a series of steps that when applied to highlevel, data-parallel programs written in the Proteus programming language yield parallel execution on a variety of different parallel architectures. The Data Parallel Library (DPL) d...

Modern field programmable gate arrays (FPGA) are capable of implementing complex system on chip (SoC) and providing high performance. Therefore, FPGAs are finding wide application. A complex SoC generally contains embedded cryptographic cores to encrypt/decrypt data to ensure security. These cryptographic cores are computationally secure but their physical implementations can be compromised usi...