To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

the goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. the mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); the prepared nanoparti...

pegylated polypropyleneimine (ppi) dendritic scaffold was used for the delivery of an anti-leukemic drug, imatinib. the current study evolves and emerges the use pegylated ppi dendritic scaffold for the delivery of this drug. in this imatinib was synthesized and loaded with pegylated ppi dendritic scaffold. parameters such as ft-ir, nmr, sem, drug release, dsc and hemolytictoxicity are required...

In the long-term management of ulcerative colitis patients, repeat dosing maybe required. Since 5-ASA is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-ASA deliver...

The aim of writing this review on gastro retentive and floating drug delivery system was to compile the new literature with the principle mechanism of floatation to acquired gastric retention. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. In floating multiple unit and single unit system are design and their cl...

The buccal mucosa lines the inner cheek, and buccal formulations are placed in the mouth between the upper gingivae (gums) and cheek to treat local and systemic conditions. The buccal route provides one of the potential route for typically large, hydrophilic and unstable proteins, oligonucleotides and polysaccharides, as well as conventional small drug molecules. The oral cavity has been used a...

6.1 pharmacosomes 6.2 neosomes 6.3 discosomes 6.4 pharmacosomes 6.5 nanoparticles 7. Various chemical approaches for ocular drug delivery 7.1 chemical drug delivery system:-7.2 enhancement of permeability by ion pair effect 7.3 soft drug approach

although the conventional therapies have obviously improved the conditions of patients with cancer, some mechanisms of resistance have led scientists to use alternative agents that can penetrate in most solid tumors. furthermore, the success of cancer therapies depends on limiting the uptake of toxins to normal tissues and their selectivity to malignant cells. the involvement of natural and gen...

Pulmonary drug delivery is primarily use to treat conditions of the airways, delivering locally acting drugs directly to their site of action. These routes of drug delivery may give the advantages like small amount of drug, less adverse reaction and rapid onset of action. The human respiratory system is complicated organ system these system consist of two reagions conducting airways and respira...