Since last 15 years the number of 505(b)(2) filings with new dosage forms for existing drug molecules at United states Food and Drug Administration (USFDA) has been increased tremendously. This is because of the tremendous increase in the developmental cost of new chemical entities (NCE) and increased concerns about patient preferences and market demands for the novel unconventional dosage form...

Oral drug delivery is most preferred route of drug delivery. Novel technologies with improved performance, patient compliance, and enhanced quality have emerged in the recent past. Sustained release dosage forms aimed at controlling the rate of release as well as maintaining desire drug level in the blood for long duration. An oral suspension could be the best suitable dosage form for geriatric...

Conventional oral dosage forms suffer with many disadvantages. To avoid such limitations controlled release dosage forms are preferred. When these controlled release dosage forms administered by oral route retained in the stomach and release the drug in a controlled fashion continuously in gastrointestinal tract [1]. Controlled release systems also suffer with some limitations such as short gas...

In the present update on ocular drug delivery system, particulate carrier, the tremendous advances in ocular drug delivery system, the polymers used in particulate carriers for ocular dosage forms, the use of drug complexes and other technological advances are discussed. This review focuses on recent literature regarding mucoadhesive particulate dosage forms with special attention to in vivo st...

Some empirical studies and recent developments in pharmacokinetic theory suggest that statistical random-effects linear models are valuable tools that allow describing simultaneously patient populations as a whole and patients as individuals. This remarkable characteristic indicates that these models may be useful in the development of personalized medicine, which aims at finding treatment regi...

Controlled release drug delivery systems 1 are those dosage formulations designed to release an active ingredient at rates, which differ significantly from their corresponding conventional dosage forms. The controlled release drug delivery systems are aimed at controlling the rate of drug delivery, sustaining the duration of therapeutic activity and/or targeting the delivery of the drug to a ti...

Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sus...

Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery system may be designed to enable prolonged residence time of the dosage form at the site of application or absorption and facilitate an intimate contact of the dosage for...