Drug induced liver disease is one of the most important causes of drug withdrawals post marketing. The liver is an engine that creates and stores energy, metabolises and detoxifies chemicals through various pathways, each of which can be a target of liver injury. Corroboration with animal studies is not optimal; pre registration studies do not have sufficient numbers to identify injury causing ...

patients with psychiatric disorders are usually more exposed to multiple somatic illnesses, including liver diseases. specific links are established between psychiatric disorders and alcohol hepatitis, hepatitis b, and hepatitis c in the population as a whole, and specifically in drug abusers. metabolic syndrome criteria, and associated steatosis or non-alcoholic steato-hepatitis (nash) are fre...

Herbal and dietary supplement (HDS) use has grown exponentially in the United States. Unfortunately, incidence of HDS-related liver injury proportionally increased. Despite potential for certain HDSs to cause clinically significant injury, they are not regulated by Food Drug Administration. Recent efforts have been made regulate but far removed from scrutiny prescription medications. Scant lite...

Although drug-induced liver injury is common, physician awareness of specific drug reactions is often limited. Celecoxibinduced drug injury has not been widely reported. We describe the case of a 28 year-old woman who presented to the emergency department with cholestatic liver injury following 13 days of celecoxib use. We searched the literature and reviewed existing case reports of celecoxib-...

Drug-induced liver injury (DILI) is a leading cause of liver failure and an important safety issue in drug development. Thalidomide is nowadays used for the treatment of several conditions including multiple myeloma (MM). Several adverse effects have been described but liver toxicity was seldom reported. We describe a case of thalidomide-induced hepatitis in a man treated for MM. The clinical s...

Drug-induced liver injury (DILI) is increasingly being recognised as a significant cause of both acute and chronic liver disease. The most commonly implicated agents are paracetamol, antimicrobials, non-steroidal anti-inflammatory drugs, statins, isoniazid and herbal remedies. Drug-induced hepatotoxicity is generally idiosyncratic in nature. The pathogenesis of DILI remains enigmatic, but invol...