Acinetobacter baumannii, a gram negative bacteria, has emerged as critical pathogen responsible for nosocomial and other infections. A. baumannii exhibits resistance to variety of antibiotic classes, emphasizing that new therapeutic targets are urgently needed. In ATCC 179778, 458 genes have been identified essential genes, indispensable growth survival the pathogen. The functions 47 proteins e...

conclusions based on the location of detected rccs in the structure of hbv proteins, it was found that these rccs may have a critical role in correct folding of hbv proteins and can be considered as drug targets. the results of this study provide new and deep perspectives about structure of hbv proteins for further researches and designing new drugs for treatment of hbv. results the pfam search...

Yersinia enterocolitica is an important pathogen to animals and humans. Thirteen strains of Y. enterocolitica were isolated from diseased fish. The partial 16SrDNA gene, five virulence genes, pathogenicity, and drug resistance of Y. enterocolitica strain G6029 were studied using molecular biological technology and toxicological method. Results showed that the length of amplified 16SrDNA sequenc...

Significance Replication stress can affect development and is a hallmark of cancers. Warsaw breakage syndrome developmental disorder caused by mutations in the conserved DDX11 DNA helicase. Here, using human cellular models deficiency, we report that helicase prevents replication mediates homology-directed repair via homologous recombination. Mechanistically, promotes resection, enabling RPA RA...

Alzheimer's disease (AD) is the most common form of dementia. It is the sixth leading cause of death in old age people. Despite recent advances in the field of drug design, the medical treatment for the disease is purely symptomatic and hardly effective. Thus there is a need to understand the molecular mechanism behind the disease in order to improve the drug aspects of the disease. We provided...

We prove that the universal rational sl3 link homologies which were constructed in [3, 7], using foams, and in [4], using matrix factorizations, are naturally isomorphic as projective functors from the category of links and link cobordisms to the category of bigraded vector spaces.

In this article, we show that magnitude homology and path are closely related, give some applications. We define differentials MH k ℓ ( G ) ⟶ − 1 $\operatorname{MH}^{\ell }_k(G) \longrightarrow \operatorname{MH}^{\ell -1}_{k-1}(G)$ between homologies of a digraph $G$ , which make them chain complexes. Then its $\mathcal {MH}^{\ell }_k(G)$ is non-trivial homotopy invariant in the context ‘homoto...

Mycobacterium ulcerans, the causative agent of Buruli ulcer, is the third most common mycobacterial disease after tuberculosis and leprosy. The present treatment options are limited and emergence of treatment resistant isolates represents a serious concern and a need for better therapeutics. Conventional drug discovery methods are time consuming and labor-intensive. Unfortunately, the slow grow...