Chemotherapy research highly prioritizes overcoming the multidrug resistance (MDR) in human tumors. Liposomal formulation of fluoxetine, as a fourth generation chemosensitizer, was constructed and characterized for percent entrapment, release profile, morphology, particle size, zeta potential and stability. Liposomes were prepared using different active loading techniques. The influence of diff...

multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...

Cancer is a main public health problem all over the world. It affects millions of humans no matter their age, gender, education, or social status. Although chemotherapy is the main strategy for the treatment of cancer, a major problem limiting its success is the intrinsic or acquired drug resistance. Therefore, cancer drug resistance is a major impediment in medical oncology resulting in a fail...

Resistance evolution is a common problem in cancer therapy, especially for genetically heterogeneous tumors that may harbor resistant subpopulations at the onset of treatment. Thus, designing therapeutic regimens that inhibit the spread of resistance is an important problem. Since higher drug concentrations increase the fitness of resistant cells, drug concentrations below the maximum tolerated...

Abstract Diffuse midline gliomas (DMGs) and other high-grade (HGG) are the most commonly lethal intrinsic brain tumors of childhood. Accordingly, novel treatment approaches needed that consider heterogeneity these tumors. Using an extensive pharmacological screen, we identified several two-drug combinations were particularly effective against a range DMG HGG cell lines, active being combination...

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their intracellular site of action. In this study, we investigated the anticancer efficacy of doxorubicin in combination with photodynamic therapy using methylene blue in a drug-resistant mouse tumor model. Surfactant-po...

PURPOSE Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult to predict the individual response of tumors. The concept of individualized therapy aims to determine in vitro the drug response of tumors beforehand to choose effective treatment options ...

background and aims: lamivudine is amongst the antiviral for drug chronic hepatitis b treatment. during therapy with lamivudine, variants may emerge with ymdd mutation in the reverse transcriptase (rt) region of polymerase gene. this mutation might have a role in drug resistant for hbv. materials and methods: hbv dna extraction from serum sample of 88 patients, were subjected to nested pcr for ...

b a ckground: the brown-banded cockroach, supella longipalpa is known as a carrier of pathogenic bacteria in urban environments, but its role is not well documented regarding the carriage of antibiotic-resistant pathogenic bacte- ria in iran. the aim of this study was to determine the resistance bacteria isolated from the brown-banded cockroach in ahvaz, south west of iran. m e t hods: totally ...

background and objectives : due to the extensive use of antibiotics, the spread of drug-resistant bacteria is one of the most worrisome threats to public health. one strategy that can be used to overcome potential shortcomings might be the inactivation of these organisms by photodynamic therapy. in this study, we have investigated whether drug-resistant wound-associated organisms (staphylococcu...