Selective Separation Sintering (SSS) is a powder layer based Additive Manufacturing approach. SSS can fabricate high temperature ceramic and metallic parts at comparatively lower cost with high quality. In the printing process a dry powder of higher sintering temperature is deposited into the base material which makes up the part. The inserted powder defines the boundary of the part and separat...

MCC was made from cotton linter using mild acid hydrolysis in 2.5 M solution of HCl at 105° for 1 hour. For the SAXS experiments, MCC powder was immersed in distilled water, ethanol, and acetone about 3 weeks prior to the measurements. Also, dry MCC powder was measured using SAXS to be able to compare the MCC-solvents with the dry state. The previously done wide-angle x-ray scattering (WAXS) st...

Topically inhaled bronchodilators and corticosteroids are the mainstay of treatment for asthma and chronic obstructive pulmonary disease. These medications are delivered via jet or ultrasonic nebulizer, metered-dose inhaler (MDI), or dry powder inhaler (DPI). While the number of devices may be confusing to patients and clinicians, each device has distinct advantages and disadvantages. Most clin...

BACKGROUND Handheld inhalers are used to deliver treatment for COPD. Incorrect usage leads to suboptimal disease control. Complex treatment regimens and use of multiple inhalers may reduce patient compliance. The Anoro Ellipta™ dry powder inhaler (DPI) simultaneously delivers umeclidinium bromide (UMEC) and vilanterol (VI) without coformulation being required. AIM To assess the correct usage ...

In this work, an ultrasonic spray freeze-drying (USFD) technique was used to prepare a stable liposomal dry powder for transdermal delivery of recombinant human epithelial growth factor (rhEGF). Morphology, particle size, entrapment efficiency, in vitro release, and skin permeability were systematically compared between rhEGF liposomal dry powder prepared using USFD and that prepared using a co...

We have investigated the effect of giving two 25 mg doses of dry surfactant powder to the airways of 10 preterm babies with severe idiopathic respiratory distress syndrome requiring intermittent positive pressure ventilation. No useful change in static total compliance or blood gases was seen. We conclude that dry surfactant powder does not have a role in the management of severe idiopathic res...

The pulmonary route is an interesting route for drug administration, both for effective local therapy (asthma, chronic obstructive pulmonary disease or cystic fibrosis) and for the systemic administration of drugs (e.g., peptides and proteins). Well-designed dry powder inhalers are highly efficient systems for pulmonary drug delivery. However, they are also complicated systems, the the performa...

Correspondence to Professor J Stuart Elborn; [email protected] Inhaled antibiotics are the backbone of care for people with cystic fibrosis (CF) who have lung infection due to Pseudomonas aeruginosa. They have significantly contributed to the improved quality of life (QOL) and increased survival in people with this disease. The systematic application of antibiotic eradication therapy for new o...

Timothy M. Crowder, PhD, is chief technology officer at Oriel Therapeutics, Inc., PO Box 14087, Research Triangle Park, NC 27709, tel. 919.313.1290 ext. 11, fax 919.313.1295, [email protected]. ctive dry-powder inhalers (DPIs) for pulmonary drug delivery have been under development for at least 10 years, but to date no such device has been approved by FDA. Like propellant-driven me...

The effects of the flow and packing properties of a drug/carrier powder mixture on emission of drug adhering to the carrier from capsules and inhalation devices were investigated. Model powder mixtures were designed consisting of lactose carriers with different particle shapes were prepared by surface treatment and micronized salbutamol sulfate. These powder mixtures were aerosolized by a Spinh...