background gastric dysplasia (gd) is a precursor lesion of gastric adenoâ­carcinoma. intestinal type gastric carcinoma commonly shows microsatellite instability (msi) and the diffuse type is associâ­ated with down regulation of e-cadherin. her-2/neu is over-expressed in some cases of gastric cancer. in this study, msi and expression rates of her-2/neu and e-cadherin in gd were evaluated. me t h...

objective: the appropriate interaction between a blastocyst and the endometrium is essential for successful implantation. numerous factors, including hormone receptors (progesterone receptor), cytokines [leukemia inhibitory factors (lif)], and adherence molecules such as e-cadherin are involved in the cross-talk that occurs between the embryo and endometrium. studies show that a lack of these g...

conclusions according to this observation, another factor such as oncogenes activity may cause cancer in samples but ct genotype of mthfr can be considered as an effective factor in creating cancer. results methylation status of e-cadherin gene numbers of methylated cases in the cancer group were equal to one and unmethylated cases equal to 33 and numbers of unmethylated cases in the non-cancer...

Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...

Loss of expression of the E-cadherin cell-cell adhesion molecule is important in carcinoma development and progression. Because previous data suggest that loss of E-cadherin expression in breast carcinoma may result from a dominant transcriptional repression pathway acting on the E-cadherin proximal promoter, we pursued studies of cis sequences and transcription factors regulating E-cadherin ex...

Background: Endometriosis, a gyncological disorder,benign and common cause of infertility, is defined as the presence of endometrial glands and stroma at ectopic locations outside the uterine cavity. Clinical observations have led to the assessment that endometriosis is an invasive disease. Abnormal expression of adhesion molecules such as cadherins is likely to be an important determinant of l...

Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting advanced stages of the disease. The role of epithelial-mesenchymal transition (EMT) in tumorigenesis in HNSCC remains unexplored. The current ...

SummaryBackground: Hair follicles are produced in a cyclical manner and the machinery involved reproduction of these is present since fetal stage. Although extensive research has been done on human hair follicle, very little known about importance adhesion molecules its development. Methods: We analyzed here, immunoexpression beta-1 integrin, p-cadherin, e- cadherin, beta-catenin from 26 formal...