Heme-copper oxidases (HCuOs) are the last components of the respiratory chain in mitochondria and many bacteria. They catalyze O(2) reduction and couple it to the maintenance of a proton-motive force across the membrane in which they are embedded. In the mitochondrial-like, A family of HCuOs, there are two well established proton transfer pathways leading from the cytosol to the active site, th...

Article history: Received 13 January 2011 Received in revised form 7 May 2014 Available online xxxx JEL classification: D51 E20 E32 E63

The development of the financial system is shown, both historically and in contemporary data, to be adversely affected by inequality in the distribution of land. To accommodate these empirical findings, a theory is developed that highlights the incentives of landowners to oppose competition in the financial sector. The theory provides an explanation for the co-incident development of the financ...

Sayan Mukherjee CBCL, MIT E25-201 Cambridge, MA 02142 [email protected] A new method for multivariate density estimation is developed based on the Support Vector Method (SVM) solution of inverse ill-posed problems. The solution has the form of a mixture of densities. This method with Gaussian kernels compared favorably to both Parzen's method and the Gaussian Mixture Model method. For synthetic ...

Enerji ihtiyacını karşılamak için ülkemizde olduğu gibi dünya genelinde de hâlihazırda petrol türevli yakıtlar kullanılmaktadır. Artan sanayileşme ve nüfus yoğunluğu buna bağlı olarak taşıt miktarı ile birlikte petrole olan eğilim daha da artmakta, bu durum kaynakların tükenmesine yol açmaktadır. Petrol rezervlerinin gün geçtikçe azalması petrolün çevreye olumsuz etkileri göz önüne alındığında ...

Omalizumab (anti-IgE ab) is a recombinant humanized monoclonal antibody (rhuMAb-E25) developed by immunizing mice with human IgE. Then, a monoclonal antibody was selected that recognizes IgE at the same site as the highaffinity receptor for IgE (FcεRI). Omalizumab is the only Mab to date that has been found to be effective and approved by both the FDA and European Medicines Agency (EMA) for the...

Article history: Received 20 August 2010 Received in revised form 24 October 2013 Available online 31 October 2013 JEL classification: E32 D43

s from the Emerging Science Series . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 Circulation Topic Review Circulation Editors’ Picks: Most Read Articles in Cardiovascular Imaging The Editors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Disorders of the maternal-placental-fetal unit often results in fetal brain injury, which in turn results in one of the highest burdens of disease, because of the lifelong consequences and cost to society. Investigating hypoxia-ischemia in the perinatal period requires the factoring of timing of the insult, determination of end-points, taking into account the innate development, plasticity, and...