Fibrodysplasia (myositis) ossificans progressiva (FOP) is a rare autosomal dominant disorder in which there is a progressive ectopic ossification and skeletal malformation, mainly in the connective tissue of muscle. The diagnosis is based on the clinical findings and radiological demonstration of the skeletal malformations. We report a 5 year-old female case with FOP.

Heterotopic ossification (HO) is characterized by the formation of bone at atypical sites. This type of ectopic bone formation is most prominent in skeletal muscle, most frequently resulting as a consequence of physical trauma and associated with aberrant tissue regeneration. The condition is debilitating, reducing a patient's range of motion and potentially causing severe pathologies resulting...

Petrified ear Pinnal ossification Exposure to hypothermia Auricular calcification Ectopic ossification Abstract A case of an otherwise healthy 66-year-old male with bilateral symmetric ossification of his ears is described. The rare occurrence of petrified ears is emphasized, and possible etiologic factors are discussed. No other explanation than anamnestic prolonged exposure to hypothermia was...

indomethacin in the prevention of heterotopic ossification after total hip arthroplasty. J Arthroplasty 2004; 19:14–8 3. Kolbl O, Knelles D, Barthel T, Kraus U, Flentje M, Eulert J: Randomized trial comparing early postoperative irradiation versus the use of nonsteroidal antiinflammatory drugs for prevention of heterotopic ossification following prosthetic total hip replacement. Int J Radiat On...

different ossificant materials have been used for induction of bone repair in many studies, and bone matrix gelatin which contains bone morphogenic proteins is one of the best ones. in present study we evaluated the role of this material in acceleration of bone repair in rabbit tibia. a hole of 3.5 mm diameter was made on right tibia of 10 and 12 rabbits as study and control group respectively....

For many years it has been recognized that changes may take place in the skeletal bony and soft tissues in paraplegic patients. Madame Dejerine and her co-workers described such changes in 1918 and 1919 (Dejerine and Ceillier, 1918; D1jerine, Ceillier and Dejerine, 1919). War injuries, road and industrial accidents have been responsible for an increased number of paraplegic patients, many of wh...

BACKGROUND Ectopic chondrogenesis and ossification were observed in a degenerative collagenase-induced calcific tendinopathy model and to a lesser extent, in a patellar tendon traumatic injury model. We hypothesized that expression of bone morphogenetic protein-2 (BMP-2) contributed to ectopic chondrogenesis and ossification. This study aimed to study the spatial and temporal expression of BMP-...

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder with diffuse extra-skeletal bone formation. The genetic mutation responsible for FOP has recently been discovered and is connected with excessive activation of bone morphogenetic protein receptor. This disease usually begins with typical ossification pattern in early childhood, causing increasing disability and ma...