Secreted metalloproteases have diverse roles in the formation, remodeling, and the destruction of extracellular matrix. Recessive mutations in the secreted metalloprotease ADAMTS17 cause ectopia lentis and short stature in humans with Weill-Marchesani-like syndrome and primary open angle glaucoma and ectopia lentis in dogs. Little is known about this protease or its connection to fibrillin micr...

The management of ectopia lentis in Marfan's syndrome is challenging. Multiple disease-associated factors conspire to deprive these patients of adequate vision. While optical correction with glasses and contact lenses is usually advocated early on, the irregular astigmatism and even partial aphakia that accompanies advanced cases generally warrant surgical intervention. Several surgical strateg...

A rare case of bilateral ectopia lentis with isolated lens coloboma in Marfan syndrome is reported. A 21-year-old female presented with decreased vision in both eyes. Her unaided visual acuity was 20/200 and 20/400 in the right and left eye, respectively, improving to 20/40 with -4.5 DS/-3.0 DC x 10° correction in the right eye and 20/80 with -10.0 DS/-6.5 Dc x10° correction in the left eye. On...

We report a case of ectopia lentis and central serous chorioretinopathy in a young female patient with several manifestations of Marfan syndrome in the skeletal, cardiovascular and dermatological systems. We can't conclude however that these two ocular abnormalities are linked.

BACKGROUND Complementary and alternative medicine (CAM) is subject to heated debates and prejudices. Studies show that CAM is widely used by psychiatric patients, usually without the guidance of a therapist and without the use of a solid working method, leading to potential health risks. AIM The purpose of this study is to facilitate the judicious use of CAM alongside conventional psychiatry ...

Burch (1936), in a comprehensive review, was largely responsible for furthering recognition of the condition in America, and the number of cases that have been reported, mostly in the ophthalmological literature, during the past ten years is an indication that arachnodactyly is not of extreme rarity, and that many milder cases and 'formes frustes ' have previously passed unrecognized. Stewart (...

3. Arch. d'Ophtal., Vol. LIII, p. 166, 1936. 4. WEEKERS, L. and FANCHAMPS, J.-Arch. d'Ophtal., Vol. I, p. 585. 1937. 5. WEEKERS, L.-Bull; Soc. Ophtal , Paris. Nancy, 16 juin, sdance consacr6e au traitement mddical du glaucome. 1939. 6. WEEKERS, L. and BONHOMME, F.-Obhthalmologica, Vol. XCIX, p. 180, 1940. 7. WEEKERS, L.-Bull. Soc. belge d'O5htal., fdvrier, 1948. 8. WEEKERS, R. and HEINTZ, A.-Bu...

PURPOSE Standard evaluation of aberrations from wavefront slope measurements in patients implanted with a rotationally asymmetric multifocal intraocular lens (IOL), the Lentis Mplus (Oculentis GmbH, Berlin, Germany), results in large magnitude primary vertical coma, which is attributed to the intrinsic IOL design. The new proposed method analyzes aberrometry data, allowing disentangling the IOL...