MicroRNAs (miRNAs) have quickly emerged as important regulators of mammalian physiology owing to their precise control over the expression of critical protein coding genes. Despite significant progress in our understanding of how miRNAs function in mice, there remains a fundamental need to be able to target and edit miRNA genes in the human genome. Here, we report a novel approach to disrupting...

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Thi s puper eztcn,ds the caging theory of R i m o n and Bluke [ill for. orre-parameter two-finger grippers t o orwparame tar three-finger grippers. T h e caging theory describes lroui the f ingers of a robot gripper can be placed uroumd u n object so tha t it cannot escape. A s the fiingers close f r o m such a configuration, the f reedom of the object t o move is gradually restricted, unti l ,...