Offspring produced by nuclear transfer (NT) have identical nuclear DNA (nDNA). However, mitochondrial DNA (mtDNA) inheritance could vary considerably. In sheep, homoplasmy is maintained since mtDNA is transmitted from the oocyte (recipient) only. In contrast, cattle are heteroplasmic, harboring a predominance of recipient mtDNA along with varying levels of donor mtDNA. We show that the two nonh...

Several fertility clinics in the United States are experimenting with ooplasm transfer. This technique is hypothesized to enhance fertility in women who have failed conventional in vitro fertilization due to poor embryo development. It involves injection of cellular material (cytoplasm or ooplasm) from a donor egg into the mother’s unfertilized egg prior to fertilization in vitro. The transferr...

background: despite the meager role of the masculine agent in infertility (the low number of infertile men than women infertile), there are men whose wives are unable to become pregnant due to the absence of sperm, decreased numbers of sperm or lack of sufficient motile sperm. utilizing donated sperm is a method that enables these families to have children. the use of this method prompts us to ...

Background Despite considerable advances in reproductive technology, its application is like a double-edged sword, which is associated with numerous challenges. One of the most challenging issues for couples is disclosure of conception circumstances to the offspring. The purpose of this qualitative study was to explore the decisions of infertile couples undergoing assisted reproductive donation...

OBJECTIVE The aim of this study was to investigate whether N680S FSHR polymorphism has a predictive value for the ovarian response to stimulation with gonadotropins and cycle outcome in our egg donor program. METHODS The oocyte donor candidates were selected according to the Instituto Bernabeu egg donation program requirements and ASRM and ESHRE guidelines for oocyte donation. The FSHR polymo...

BACKGROUND Findings are presented of the second phase of a longitudinal study of families created through gamete donation. METHODS At the time of the child's second birthday, 46 donor insemination families and 48 egg donation families were compared with 68 natural conception families on standardized interview and questionnaire measures of the psychological well being of the parents, parent-ch...