Treatment failure in high risk neuroblastoma (NB) is largely due to the development of chemotherapy resistance. We analyzed the gene expression changes associated with exposure to chemotherapy in six high risk NB tumors with the aid of the Connectivity Map bioinformatics platform. Ten therapeutic agents were predicted to have a high probability of reversing the transcriptome changes associated ...

Max-Planck-Institut für Radioastronomie, Bonn, Germany, Department of Physics and Astronomy, University of Texas at San Antonio, San Antonio, TX, United States, 3 Instituto Nacional de Astrofísica Óptica y Electrónica, Puebla, Mexico, 4 SOFIA Science Center, NASA Ames Center, Mountain View, CA, United States, Centre for Remote Sensing and Earth Observation Processes (TAP), Flemish Institute for...