吉村 政弘 ・蕪城 外枝子 * This work was supported , in part, by grants from the Japan Anti-Cancer Society, the National Institute of Health, U. S. A., and the Tokyo Biochemistry Research Fund. Attempts to induce immunity against Ehrlich ascites carcinoma in inbred mice have been the subject of considerable studies in recent years (1-4). Various procedures were employed with varying degrees of success to ...

In an effort to discover an effective and selective antitumour agent, synthesis and anti-cancer potential of 4-(pyridin-4-yl)-6-(thiophen-2-yl)pyrimidin-2(1H)-one (SK-25), which has been reported earlier by us with significant cytotoxicity towards MiaPaCa-2 malignant cells, with an IC50 value of 1.95 μM and was found to instigate apoptosis. In the present study, the antitumour efficacy of SK-25...

The antitumor effects of 6-mercaptopurine (6MP) and 6-(methylmercapto)purine ribonucleoside (MeoMPR) are dis tinctly potentiated when these agents are used together in the treatment of certain mouse tumors, including the Ehrlich ascites carcinoma. This paper is concerned with the biochem ical mechanism of this potentiation. Prior treatment of Ehrlich ascites carcinoma cells with MeoMPR enhanced...

This study was designed to determine the in vitro anticancer potential of Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer swiss albino mice. The activity assessed using cytotoxicAity, mean survival time, tumor volume and hematological studies. reliable criteria for evaluating any agent is prolongation lifespan animal decrease WBC count b...

Using a recently developed technique of direct tracer injection into selective adipose tissue sites (Baker et al., Mech. Ageing Dev., 27: 295-313, 1984), we have studied the esterification of free fatty acids (FFA) to triglyceride fatty acids in the epididymal fat pads of normal and Ehrlich ascites carcinoma-bearing mice. We have tested the hypothesis that, during Ehrlich ascites carcinoma grow...

1. The histological and physiological characteristics in vitro of mouse tumors have been compared. 2. Twenty-eight adenomas, 31 adenocarcinomas, 18 carcinomas, and a series of tumors from 2 transplantable carcinomas and from Ehrlich carcinoma have been cultivated in vitro. 3. The adenomas were characterized by cells of normal appearance, migrating quickly and organizing in thin membranes, by fe...

The antitumor effects of 6-mercaptopurine (6MP) and 6-(methylmercapto)purine ribonucleoside (MeoMPR) are dis tinctly potentiated when these agents are used together in the treatment of certain mouse tumors, including the Ehrlich ascites carcinoma. This paper is concerned with the biochem ical mechanism of this potentiation. Prior treatment of Ehrlich ascites carcinoma cells with MeoMPR enhanced...

The aim of this study was to enhance the understanding of the antitumor mechanism of 1,4-naphthoquinones and ascorbate. Juglone, phenylaminonaphthoquinone-7, and 9 (Q7/Q9) were evaluated for effects on CT-DNA and DNA of cancer cells. Evaluations in MCF-7 cells are DNA damage, ROS levels, viability, and proliferation. Proteins from MCF-7 lysates were immunoblotted for verifying PARP integrity, γ...