This study was designed to determine the in vitro anticancer potential of Astaxanthin isolated from shrimp shell waste (ETC) against Ehrlich Ascites Carcinoma (EAC) induced cancer swiss albino mice. The activity assessed using cytotoxicAity, mean survival time, tumor volume and hematological studies. reliable criteria for evaluating any agent is prolongation lifespan animal decrease WBC count b...

The antitumor activity of 2,3-dihydroxybutyraldehyde on Ehrlich carcinoma, Sarcoma 180, and Yoshida AH 130 hepatoma, as well as the aldehyde dehydrogenase activity in these tumors, was studied. 2,3-Dihydroxybutyraldehyde at nontoxic doses (500 mg/kg body weight i.p. daily for 7 days) slowed down the growth of solid and ascites tumors in mice. The treatment completely prevented the development o...

The effect of an in vivo treatment with two commonly employed drugs that are P-glycoprotein substrates, verapamil and rifampicin, on Ehrlich ascites carcinoma cells, was evaluated. Ehrlich ascites carcinoma cells were inoculated i.p. in CD-1 mice and animals were orally treated for 10 days with rifampicin (60 mg/kg/day) or verapamil (6 mg/kg/day). In the harvested cells the transcripts for mdr1...

SAITO, T., WAKui, A., KIKKAWA, J., KUDO, T., KIKUCHI, K. and ICHIKAWA, T. Fluctuation of Lipid Content in Ehrlich Carcinoma Cells during the Growth Period. Tohoku J. exp. Med., 1972, 108 (1), 63-77 -1) Total lipid content in Ehrlich ascites carcinoma cells decreased gradually with considerable fluctua tions in the course of cell growth. There was also remarkable fluctuation in individual lipid ...

Many streptomyces strains produced an inhibitor of crude glyoxalase prepared from rat liver which did not inhibit glyoxalase I prepared from yeast. Another inhibitor, C11H14O6, which inhibited glyoxalases prepared from both rat liver and yeast was obtained from a cultured broth of Streptomyces griseosproeus and crystallized. Preincubation of this inhibitor with reuduced glutathione increased it...

Egg lectin of Rana japonica, which specifically agglutinates transformed cells but does not agglutinate nontransformed cells and erythrocytes, has been isolated by gel filtration and successive ion-exchange chromatographies on diethylaminoethyl cellulose and carboxymethylcellulose columns and has been characterized as a homogeneous carbohydrate-free protein with a relative molecular weight of 1...

The present study was concerned with the pharmacological potency of zizyphus leaves extract towards antitumor in the form of Ehrlich ascites carcinoma (EAC) model in female albino mice. Ascites tumor was introduced into mice by inoculation of 2 x 10 viable tumor cells/mouse. After 10 days of transplantation, the extraction of zizyphus leaves was given daily for 21 days via intraperitoneal route...

The antitumor activity of a new antibiotic, stubomycin, against various murine tumors was studied. Stubomycin showed antitumor activity against Sarcoma 180, IMC-carcinoma and Meth-A tumor. In particular, all of the mice inoculated i.p. with IMC-carcinoma were cured when they were given nine successive injections of stubomycin. Stubomycin also showed remarkable antitumor effects against Sarcoma ...