This study aims to identify and define the type and frequency of elastotic alterations of vessels and ducts in pancreatic ductal carcinoma (PDAC) and evaluate its diagnostic significance. Representative tissue from 36 Whipple specimens, stained with Verhoeff's Van-Gieson, was studied focusing on the density and distribution of elastic fibers in walls of vessels and ducts, in perivascular and pe...

OBJECTIVE Determination of histopathological changes in different types of skin aging. METHODS AND RESULTS The study included a group of 60 women with various types of skin aging. Three groups were distinguished, each group containing 20 individuals. Group I consisted of women with menopausal skin aging, Group II with photoaging, and Group III with chronological aging. Biopsy specimens were t...

Andersen, D. H., and Kelly, J. (1956). Endocardial fibro-elastosis: I. endocardial fibro-elastosis associated with congenital malformations of the heart. Pediatrics, 18, 513, Dordick, J. R. (1951). Diffuse endocardial fibrosis and cardiac hypertrophy in infancy: report of two cases in consecutive siblings. American Journal of Clinical Pathology, 21, 743. Forfar, J. O., Miller, R. A., Bain, A. D...

Elastofibromatous change is a benign process that has been increasingly recognized in the tubular gastrointestinal tract. These changes can present as a colonic polyp or be seen in conjunction with inflammatory changes. Similar lesions have been noted in the liver, apparently associated with vascular injury. We describe a case in which multiple circumscribed nodules of elastofibromatous change ...

The goal of this thesis study was to understand the role of TGF-3 in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracellluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar elastosis are poorly understood. TGF-3 is a multifunctional cytokine involved in the regulatio...

Solar ultraviolet radiation (UVR) exposure is clearly associated with increased mortality from non-melanoma skin cancer – usually squamous cell carcinoma. However, the association with cutaneous melanoma is unclear from the evidence in ecologic studies, and the few analytic studies that have been published show that high levels of intermittent UV exposure prior to diagnosis are associated with ...