Complex traits are often manifested by multiple correlated traits. One example of this is hypertension (HTN), which is measured on a continuous scale by systolic blood pressure (SBP). Predisposition to HTN is predicted by hyperlipidemia, characterized by elevated triglycerides (TG), low-density lipids (LDL), and high-density lipids (HDL). We hypothesized that the multivariate analysis of TG, LD...

A parallel manipulator of STEWART GOUGH (SG) type consists of a platform and a base, which are connected via six spherical-prismatic-spherical legs, where all prismatic joint are active (actuated) and all spherical joints are passive (non-actuated). If we fix the prismatic joints, the SG platform is generically rigid, but under particular geometric conditions the manipulator can perform a n-dim...

A common practice among researchers performing linkage studies is the use of equal allele frequencies as input when reporting p-values from computer linkage programs such as S.A.G.E. SIBPAL. Our results, using 5,000 sets from a uniform-prior distribution of allele frequencies, showed that such input may be problematic. Further, we found that the S.A.G.E. SIBPAL test for proportion of alleles sh...

Canada's drug companies are now getting their knuckles rapped publicly if they violate industry rules concerning the CME events they sponsor. Several rulings made by the Marketing Practices Review Committee of Canada's Research-Based Pharmaceutical Companies (Rx&D, formerly the Pharmaceutical Manufacturers Association of Canada), are published in the latest issue of the organization's newslette...

153. Kaatz S, Elston-Lafata J, Gooldy S. Anticoagulation therapy home and office evaluation (AT HOME) study. Thromb Haemost. 2001; 86(suppl):P779. Abstract. 154. Wilson R, James AH. Computer assisted management of warfarin treatment. Br Med J. 1984;289:422–424. 155. White RH, Mungall D. Outpatient management of warfarin therapy: comparison of computer-predicted dosage adjustment to skilled prof...