Background: Prostate cancer is one of the most frequent cancers in men, with several risk factors, including infection. In this study, we aimed to assess association human papillomavirus (HPV) infection prostate and aggressiveness. Methods: This case-control study was performed on a total 70 archival formalin-fixed paraffin-embedded (FFPE) prostatic tissue blocks. Among them, 35 histopathologic...

PURPOSE Considerable evidence has accumulated demonstrating that the 5alpha-reduction of testosterone to dihydrotestosterone occurs more efficiently in the normal and benign hyperplastic prostate than in prostate cancer tissues. Efforts have also been channeled into investigating the distribution of 5alpha-reductase isoenzymes in primary prostate tissues and in "in vitro" cell models of the hum...

A simple and fast time-domain method for localizing inclusions, fluorescent optical probes or absorbers, is presented. The method offers new possibilities for situations where complete tomographic measurements are not permitted by the examined object, for example in endoscopic examination of the human prostate or the oesophagus. Feasibility has been envisioned with a phantom study conducted on ...

immunohistochemical demonstration of tumor-associated markers may be valuable as an adjunct to conventional histology for determination of malignancy development in oral mucosal diseases. accordingly, the present study determined the distribution of some important tumor markers such as heat shock proteins (hsp), fibroblast growth factors (fgf) and transferrin receptors (tf-r) in 22 samples of p...

Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than 100 types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-16 and HPV-18 have shown further association with cancer. Regarding the pr...

OBJECTIVE Our aims were to measure the level of expression of Abelson (ABL1), β-glucuronidase (GUS) and glucose-6-phosphate dehydrogenase (G6PD) genes in exfoliated urine cells from healthy and transrectal ultrasound biopsy patients with elevated prostate-specific antigen levels and/or abnormal digital rectal examinations or urinary symptoms indicative of prostate problems, as well as in archiv...

DNA methylation has emerged as a potentially robust biomarker for prostate cancer (PCa). Since DNA methylomes appear to be disease as well as population specific, we have assessed the DNA methylation status of RASSF1A, APC, and p16 (potential biomarkers of PCa) in Pakistani population. Primary prostate cancer tissues were obtained from 27 formalin-fixed paraffin-embedded blocks (FFPE) of cancer...

a simple, highly sensitive, accurate and selective method for determination of trace amounts of cu2+ in water samples was reported. in this paper, isopropyl 2-[(isopropoxy carbothioyl)disulfanyl]ethanethioate (iide) in order to prepare an effective sorbent for the preconcentration and determination of cu. the sorption capacity of isopropyl 2-[(isopropoxy carbothioyl)disulfanyl]ethanethioate (ii...

Accruing evidence indicates that exposure to environmental compounds may adversely affect human health and promote carcinogenesis. Triclosan (TCS), an antimicrobial agent widely used as a preservative in personal care products, has been shown to act as an endocrine disruptor in hormone-dependent tissues. Here, we demonstrate a new molecular mechanism by which TCS stimulates the secretion by hum...