نتایج جستجو برای: enalapril maleate

تعداد نتایج: 5057  

2012
Swamy NGN

Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...

2010
Anroop B. Nair Hiral Vyas Ashok Kumar

Hydroxy propyl methyl cellulose (HPMC) is generally combined with hydrophobic polymers in fabricating oral controlled solid dosage forms. This study evaluated the utility of diverse grades of HPMC in developing a controlled release formulation for a hydrophilic drug, enalapril maleate. Controlled release uncoated tablets were prepared by direct compression technique. Two grades of HPMC (K100 an...

Journal: :British journal of clinical pharmacology 1985
R Bergstrand H Herlitz S Johansson G Berglund A Vedin C Wilhelmsson H J Gomez V J Cirillo J A Bolognese

The dose-response relationship of enalapril was evaluated in a double-blind, balanced, two-period, incomplete-block study in 91 patients with mild to moderate essential hypertension. Patients were randomly assigned to two of six treatments: placebo, 2.5, 5, 10, 20 and 40 mg/day of enalapril maleate. There were two 3-week treatment periods, each preceded by a 4-week, single-blind placebo washout...

Journal: :British medical journal 1982
G P Hodsman J J Brown D L Davies R Fraser A F Lever J J Morton G D Murray J I Robertson

Enalapril maleate (MK421), a new inhibitor of angiotensin converting enzyme, in single daily doses of 1.25-40 mg was assessed in five patients with hypertension and renal artery stenosis. Only small falls in plasma angiotensin II concentrations were seen at doses less than 10 mg; even with 10 and 20 mg, angiotensin II concentrations had risen again 24 hours from the last dose. During long-term ...

Journal: :Clinical science 1992
M Hargreaves K Ravi M P Senaratne C T Kappagoda

1. The present study was performed in anaesthetized, artificially ventilated, open-chested rabbits to examine whether (a) the rapidly adapting receptors of the airways were stimulated by exogenously administered bradykinin, and (b) if this sensitivity could be enhanced by the angiotensin-converting-enzyme inhibitor, enalapril. 2. Rapidly adapting receptor activity (n = 8) was recorded from the ...

Journal: :Journal of Pharmaceutical & Scientific Innovation 2018

Journal: :Journal of clinical pharmacy and therapeutics 2005
T Arafat R Awad M Hamad R Azzam A Al-Nasan A Jehanli K Matalka

BACKGROUND AND OBJECTIVES Most of the pharmacokinetic (PK) parameters for enalapril and enalaprilat were established following determination of the drug and its metabolite, using angiotensin converting enzyme (ACE) inhibition assays. In these methods, enalapril has to be hydrolysed to enalaprilat first and then assayed. The purpose of this study was to re-estimate the PK parameters of enalapril...

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