BACKGROUND Amelogenesis Imperfecta (AI) is a disorder of tooth development where there is an abnormal formation of enamel or the external layer of teeth. The aim of this study was to screen mutations in the four most important candidate genes, ENAM, KLK4, MMP20 and FAM83H responsible for amelogenesis imperfect. METHODS Geneomic DNA was isolated from five Iranian families with 22 members affec...

Stage-specific expression of ameloblast-specific genes is controlled by differential expression of transcription factors. In addition, ameloblasts follow daily rhythms in their main activities (i.e. enamel protein secretion and enamel mineralization). This time-related control is orchestrated by oscillations of clock proteins involved in the regulation of circadian rhythms. Our aim was to ident...


 Penelitian ini memeriksa kasus-kasus intermediasi atau alih wahana, yang berlangsung dari naskah drama “Hamlet” (1602) gubahan William Shakespeare, khususnya solilokui ‘To be or not to be’, menjadi komik melalui adaptasi Dana E. Dutch/Henry Kiefer (1950), Sam Willinsky/Alex A. Blum (1952), Naunerle Farr /E. R. Cruz (1980), Will Eisner (1985), Steven Grant/Tom Mandrake (1990), dan Adam Se...

Although the nonamelogenin proteins, ameloblastin and enamelin, are both low-abundance and rapidly degrading components of forming enamel, they seem to serve essential developmental functions, as suggested by findings that an enamel layer fails to appear on teeth of mice genetically engineered to produce either a truncated form of ameloblastin (exons 5 and 6 deleted) or no enamelin at all (null...

Amelogenesis imperfecta (AI) represents hereditary conditions affecting the quality and quantity of enamel. Six genes are known to cause AI (AMELX, ENAM, MMP20, KLK4, FAM83H, and WDR72). Our aim was to determine the distribution of different gene mutations in a large AI population and evaluate phenotype-genotype relationships. Affected and unaffected family members were evaluated clinically and...

Stable Conjugated Prim ary Enamines, ^-C onjugation , oand .T-Effects in Conjugated Systems The structures of l,6-diam ino-l,6-diphenyl-1.3,5-hexatriene (2) and its l,6-bis(N,N-bistrim ethylsilylam ino)-derivative (3) are com pared. The X-ray crystal structure analyses of 2 and 3 show that turning off the conjugation with the nitrogen lone pairs by orthogonal orientation of the R2N-plane has no...