Pravastatin (PRAV) is a hydrophilic statin which has been reported to have antiangiogenic and pro-apoptotic effects. However, the beneficial effects of statins on tumour growth are obtained at high doses, the systemic administration of those doses being associated with severe toxicity. Thus, site-specific delivery with liposomal systems may be a novel approach in order to enrich its therapeutic...

Objective: The main objective of the study is to formulate hydrophilic drug loaded sustained release nanoparticles with the size of 200 nm and to increase the encapsulation efficiency of the drug. Methodology: The nanoparticles were prepared by simple ionic gelation method using various concentrations of chitosan and TPP. The prepared nanoparticles were evaluated for particle size, shape, charg...

Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action and systemic side effects in high doses. Liposomal formulation of anti-leishm...

We study the influence of the emulsification process on encapsulation efficiency of drugs in double water-in-oil-in-water emulsions. Two drugs were used, first vitamin B12 which can be considered as a model drug and secondly a suspension of Cydia pomonella Granulovirus (CpGV), a virus used in organic agriculture to protect fruits against the Carpocapse insect. Encapsulation is measured by class...

The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...

Resistance to aspirin and its cytotoxicity significantly limits its therapeutic applications. Nano-liposomal encapsulation of aspirin can reduce its cytotoxicity. In this study, aspirin encapsulated nano-liposomes (AS-NL) was prepared and its performance in drug delivery and cytotoxicity was evaluated. The effects of two independent variables including: number of freeze/thawing cycles and conce...

saffron essential oil has a pleasant aroma and medicinal activities. however, it is sensible into the environmental condition. therefore, it should be protected against unwanted changes during storage or processing. encapsulation is introduced as a process by which liable materials are protected from unwanted changes. in the present study, different ratios (0:100, 25:75, 50:50, 75:25, and 100:0...

objective(s): the purpose of this study was preparation and evaluation of plga nanospheres containing the influenza virus and different adjuvants, quillaja saponin (qs) and cpg-odn.   materials and methods: nanospheres were prepared using the double emulsion-solvent evaporation method. the morphological and physicochemical properties were studied by scanning electron microscopy (sem), determina...