The leaves and stems of Perilla frutescens var. acuta Kudo (PF) have been used to prevent threatened abortion in traditional medicine in the East Asian countries. Because reduced receptivity of endometrium is a cause of abortion, we analyzed the action of PF on the endometrial receptivity. PF increased the level of leukemia inhibitory factor (LIF), a major cytokine regulating endometrial recept...

However, the notion of receptivity as a static state in which the tissue is poised, frozen in time, awaiting the arrival of an adequately developed embryo, is naïve. An integrative definition of receptivity must embrace communication between maternal and embryonic tissues. At receptivity, the endometrium has reached a point at which negotiation can begin that may or may not lead to successful i...

Ovarian stimulation for IVF is known to affect luteal phase function. The endometrium in IVF cycles is thus subject to an altered endocrinological environment and to a possible direct effect of the ovarian stimulation therapy. Factors influencing the endometrial receptivity in such cycles are poorly understood. Studies comparing the endometrium in IVF cycles with natural cycles as controls have...

The presence of the conceptus in uterine cavity necessitates an elaborate network of interactions between the implanting embryo and a receptive endometrial tissue. We believe that embryo-derived signals play an important role in the remodeling and the extension of endometrial receptivity period. Our previous studies provided original evidence that human Chorionic Gonadotropin (hCG) modulates an...

The endometrium is a complex, steroid-dependent tissue that undergoes dynamic cyclical remodelling. Transformation of stromal fibroblasts (ESC) into specialised secretory cells (decidualization) is fundamental to the establishment of a receptive endometrial microenvironment which can support and maintain pregnancy. Androgen receptors (AR) are present in ESC; in other tissues local metabolism of...

background: there are some controversial data on application of progesterone and progesterone plus estrogen at luteal phase. objective: to investigate the effects of different luteal support hormones on the alkaline phosphates (alp) activity in the endometrial epithelium and endometrial thickness during superovulation process for obtaining the optimized endometrial receptivity in animal model. ...

We report a case of polycystic ovary syndrome and prolonged infertility in which endometrial intraepithelial neoplasia was reversed with high dose progesterone therapy. Spontaneous conception after failure of assisted reproductive techniques highlights the role of endometrial receptivity.

26 27 Background: The adjunction of exogenous hormones for controlled ovarian stimulation 28 (COS) may alter endometrial receptiveness. In order to identify the genes mis-regulated under 29 COS, we compared the endometrium gene expression profiles, from the same patients, in a 30 natural cycle and in a subsequent COS cycle. Methods: For the same normal-responder 31 patients (n=21), endometrial ...

results endometrial thickness in patients who had 0, 1, 2, 3 and 4 d&c; were 10.00 ± 0.58, 9.83 ± 0.47, 8.90 ± 0.92, 7.42 ± 0.18 and 7.40 ± 0.07, respectively one day before ovulation (spearman’s correlation coefficient = -0.33) and 10.62 ± 0.68, 9.64 ± 0.49, 8.48 ± 0.96, 6.32 ± 0.15 and 6.90 ± 0.04, respectively, 5-7 days after ovulation (spearman’s correlation coefficient = -0.66) estradiol a...