Eosinophilic granuloma of bone is a destructive osseous lesion characterized by large number of histiocytes. It is classified as one of the triad of nonlipid reticuloendothelial disorders, the Langerhans cell histiocytosis (LCH). The clinical manifestation varies from a localized lesion (eosinophilic granuloma) to a systemic disease. Typically, there is bone involvement and less frequently lesi...

PURPOSE To report the retrospective experience of a reference center in the diagnosis and treatment of orbital eosinophilic granuloma. METHODS A review of the files in the Opththalmic Pathology Laboratory, of the Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, between 1974 and 2004, was conducted to identify cases of orbital eosinophilic granuloma. Data of diagn...

Eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease are three disorders characterized by proliferating histiocytes. Collectively, they are called histiocytosis X. Histiocytosis X often presents with lytic calvarial lesions [1]. Hypothalamic involvement is the most common intracranial manifestation [2]. Solitary histiocytosis X within the cerebral hemispheres, alth...

Eosinophilic granuloma is the most common and benign form of a rare proliferative disorder: Langerhans' cell histiocytosis. Spinal involvement is rare and only 15 adult cases have been reported. We present an unusual variant of eosinophilic granuloma in a 25-year-old woman with radiological evidence of vertebra plana. Plain radiography, magnetic resonance imaging, bone scan, and blood tests wer...

PURPOSE To present rare benign orbital tumors with bone destruction in children who could not be diagnosed pre-surgically and may simulate malignant ones. METHODS A retrospective review of cases. Clinical, operative and pathological records in all children with a diagnosis of benign orbital tumors who showed remarkable bone destruction at a tertiary Ophthalmic Center in China between Jan 1, 2...

Two case reports of an uncommon type of oral ulcerative lesion are presented. These lesions are of long duration, benign and reactive, and may clinically mimic a malignant ulcer. Histologically, these are deep lesions which exhibit 'pseudoinvasion' into skeletal muscle. There is a predominance of eosinophils while other chronic inflammatory cells such as plasma cells and histiocytes are in abun...

Methods V. 29 months old comes to our hospital because of persistent lameness . The symptoms began three months before, after a trauma. For persisting pain and lameness the child was checked by an orthopaedist who diagnosed “hip transitory synovitis”. Infact radiography and ultrasonography of the hip and femoral head were negative. The child was prescribed therapy with NSAIDs. At first the chil...