Epidural scar formation after laminectomy impede surgical outcomes of decompression. Mitomycin C (MMC) has been demonstrated to have significant inhibitory effects on epidural scar. This study was undertaken to develop an effective MMC controlled‑release membrane and to investigate its effects on epidural scar in rat models of laminectomy. A total of 72 rats that underwent laminectomy were divi...

Postoperative epidural fibrosis (EF) is still a major limitation to the success of spine surgery. Fibrotic adhesions in space, initiated via local trauma and inflammation, can induce difficult-to-treat pain constitute main cause failed back surgery syndrome, which not uncommonly requires operative revision.

To define the time course and mechanism of enhancement of epidural fibrosis after gadolinium-DTPA (Gd-DTPA) injection, we undertook a three-part study in humans and dogs with epidural scar after spine surgery. First, the dynamic in vivo contrast-enhancing properties of epidural scar were assessed by using sequential fast (18-sec) spin-echo sequences after contrast injection. Epidural scar in do...

BACKGROUND TGF-β has been described as a mediator of fibrosis and scarring. Several studies achieved reduction in experimental scarring through the inhibition of TGF-β. Fibroblasts have been defined as the cell population originating fibrosis, blocking fibroblast invasion may impair epidural fibrosis appearance. For this purpose, biocompatible materials used as mechanical barriers and a TGF-β i...

AIM To investigate the effects of hyperbaric oxygen treatment on epidural fibrosis formation in an experimental laminectomy model. MATERIAL AND METHODS Twenty-four Wistar rats underwent L5-L6 total laminectomy and divided into three groups. Animals in the control group received no further treatment while animals in short and long term groups received 2,5 ATM ABS of hyperbaric oxygen for 3 and...

Abstract Background Epidural fibrosis is one of the aetiologies pain following a spinal revision surgery. It reported that specific members mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain. However, roles epidural caused by repeated surgeries and pain-related proteins in causing post surgery syndrome remain unknown. Using rat adhesion model, this study, we evalua...

Epidural fibrosis is seen as a common phenomenon among postlumbar laminectomy syndrome patients, contributing to approximately 60% of symptom recurrence. Percutaneous epidural lysis of adhesions has been described as a modality to effectively manage chronic low back pain secondary to epidural fibrosis. Forty-five patients were randomly assigned, with fifteen patients in the control group, or Gr...

BACKGROUND Failed back surgery syndrome (FBSS) has been reported to account for up to 40% of patients with chronic low back pain. Epidural fibrosis may be responsible for up to 30% of all cases of FBSS. Perineural fibrosis can interfere with cerebrospinal fluid-mediated nutrition, rendering the nerve root hyperesthetic and hypersensitive to compression. Traditionally, steroid injection has been...

BACKGROUND Epidural fibrosis (EF) is a common complication after laminectomy. Salvianolic acid B (Sal B) is a major bioactive component of a traditional Chinese medical agent, Salvia miltiorrhiza, which has shown anti-inflammatory, anti-fibrotic and anti-proliferative properties. The object of this study was to investigate the effect of Sal B on the prevention of epidural fibrosis in laminectom...

Abstract Excessive epidural fibrosis attached to the dura mater is major cause of recurrent failed back surgery syndrome after spine surgery. Neutrophil extracellular traps (NETs) promote fibrosis, raising possibility that DNA backbone NETs may be a potential target in therapy fibrosis. Human body temperature-sensitive hydroxypropyl chitin hydrogel solutions were prepared encapsulate DNase I, w...