Ovarian neoplasia comprises a heterogenous group of tumors with distinct clinicopathologic and molecular features and therefore assessment of potential risk factors should be tumor subtype specific. As part of ongoing epidemiological investigations of ovarian neoplasia in Western Australia, we performed an initial review of original pathology reports followed, in selected cases, by reassessment...

The interaction of tissue-cultured cells derived from normal squamous epithelium, normal connective tissue, and intraepithelial neoplasia of the adult human uterine cervix was studied using phase-contrast time-lapse cinematography. The fibroblasts exhibited typical, passive, contact inhibition to other fibroblasts but not to the normal epithelial cells or cells from intraepithelial neoplasia. T...

The interaction of tissue-cultured cells derived from normal squamous epithelium, normal connective tissue, and intraepithelial neoplasia of the adult human uterine cervix was studied using phase-contrast time-lapse cinematography. The fibroblasts exhibited typical, passive, contact inhibition to other fibroblasts but not to the normal epithelial cells or cells from intraepithelial neoplasia. T...

AIMS To report the distribution of histopathological diagnoses in patients who underwent excision of localised limbal lesions that were clinically suspected to be squamous neoplasia (intra-epithelial neoplasia or squamous cell carcinoma). METHODS 162 consecutive patients of a single ocular oncologist underwent an excisional biopsy between 1998 and 2009 for suspected squamous neoplasia. Histop...

AIMS To investigate the effect of combination endocrine treatment (CET) or luteinising hormone releasing hormone agonist and flutamide on non-neoplastic prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. METHODS The morphology, including the mitotic activity, of 12 radical prostatectomies from patients with prostatic adenocarcinoma pretreated for three months with CE...

OBJECTIVE conventional forceps biopsy (CFB) is the most popular way to screen for gastric epithelial neoplasia (GEN). Our study aimed to compare the diagnostic accuracy between conventional forceps biopsy and endoscopic submucosal dissection (ESD). METHODS 105 patients diagnosed GEN finally undertook ESD in our hospital were enrolled. We retrospectively assessed the characteristics of patholo...

Chronic inflammation increases the risk of developing several gastrointestinal malignancies. Chemokines that are produced by colonic epithelial cells play significant roles in the maintenance and repair of the epithelial barrier. The present study aimed to clarify whether the expression of CCL20 and its receptor, CCR6, was correlated with the development of ulcerative colitis (UC)-associated ne...

BACKGROUND The pathogenesis of colorectal neoplasia is still unresolved but has been associated with alterations in epithelial clearance of xenobiotics and metabolic waste products. The aim of this study was to functionally characterize the transport of cyclic nucleotides in colonic biopsies from patients with and without colorectal neoplasia. METHODS Cyclic nucleotides were used as model sub...

conclusions this study showed that the frequency of bilin was low among iranian patients with psc. high bilirubin and ca19-9 can be predictors of the development of bile duct epithelial changes in patients with psc. background primary sclerosing cholangitis (psc) as one of the most common chronic cholestatic liver diseases is a main predisposing factor for the development of cholangiocarcinoma ...