The antiviral response of CD8 T cells involves the differentiation of naive T cells into distinct types of effector and memory cells, which may be distinguished by the level of CD7 expression. We have investigated CD8 T cells in adults and children infected with HIV-1 to determine the disease relevance of cell subsets defined by CD7. CD8 T cells from patients infected with HIV-1 displayed profo...

A N 86-YEAR-OLD WOMAN PRESENTED WITH a few months’ history of progressive fullness in the right side of her face along with localized discomfort in her right maxillary region. She denied any trauma, nasal obstruction, diplopia, neurologic deficits, dysphagia, odynophagia, voice changes, weight loss, cough, pulmonary symptoms, fever, or chills. She also denied any history of tobacco or alcohol u...

Introduction. Among the available scientific literature, there are no publications addressing processes of self-regulation in parasite-host population systems with reference to chronic infections, including infection caused by EpsteinBarr virus (EBV infection).
 The aim study is assess manifestations epidemic process EBV through lens basic tenets theory parasitic systems.
 Materials a...

Oncogenic anaplastic lymphoma kinase (ALK) fusion proteins (NPM/ALK and associated variants) are expressed in about 60% of anaplastic large cell lymphomas (ALCLs) but are absent in normal tissues. In this study, we investigated whether ALK, which is expressed at high levels in lymphoma cells, could be a target for antigen-specific cell-mediated immunotherapy. A panel of ALK-derived peptides was...

Intravascular lymphoma (IVL) is a rare entity of extranodal large cell lymphoma. Most cases of IVL are B-cell phenotype, with a few cases of T-cell or NK-cell origin. To our knowledge, only 5 cases of intravascular cytotoxic T-cell lymphoma with sufficient phenotype studies have been reported so far. Here, a case of intravascular cytotoxic T-cell lymphoma initially occurred in epididymis in a 6...

A 9-year-old girl was hospitalized on 7th day of illness because of prolonged fever and cervical lymphadenopathy. On admission, leukopenia (total leukocyte count 1.1×109/L) and thrombocytopenia (platelet count 60×109/L) were present. Serum aspartate aminotransferase (128 U/L), alanine aminotransferase (99 U/ L), lactate dehydrogenase (518 U/L), ferritin (823 mg/ dL), soluble interleukin-2 recep...

Staurosporine, which is a potent inhibitor of protein kinases, such as protein kinase C, inhibited both inductions of adhesion of human promyelocytic leukemia cells (50% effective dose = 9.0 n.\t) and EpsteinBarr virus early antigen in Raji cells (50% effective dose = 3.4 nivi) by teleocidin. However, Staurosporine induced irritation on mouse ear and histidine decarboxylase activity in mouse sk...

B CELL lymphomas which often contain the EpsteinBarr virus (EBY) make up the preponderance of tumors that collectively have been tcrmed posttransplant Iymphoproliferative disordcrs (PTLD). The unusual susceptibility of PTLD to immune surveillance was first demonstrated in organ allograft recipients following reduction (or discontinuance) of immunosuppression I with its attendant risk of precipi...

A previously healthy 18-year-old girl with no significant medical history presented to her pediatrician in the summer with a sore throat and fatigue. Results of a rapid Streptococcus (strep) screening test and a mononucleosis spot test were both negative, and she was prescribed a 10-day course of amoxicillin for the pharyngitis. One week later, the patient returned with a diffuse rash consistin...

Designing proteins or peptides that bind native protein targets can aid the development of novel reagents and/or therapeutics. Rational design also tests our understanding of the principles underlying protein recognition. This paper describes several strategies used to design peptides to bind to the bZIP domain of the viral transcription factor BZLF1, which is encoded by the EpsteinBarr virus (...