Cisplatin (CP) is a widly used anticancer drug against abroad spectrum of malignance, but at high dose, it can produce undesirable effects such as hepatotoxicity. The aim of this study was to investigate the possible protective effect of erdosteine (Erd) against CP-induced biochemical, histopathological changes and hepatotoxicity associated with oxidative stress and inflammatory changes in male...

A simple, selective, precise and accurate stability-indicating high-performance liquid chromatographic method for analysis of Erdosteine and its degradation products in tablet dosage form was developed and validated. The stability indicating ability of the method was determined by performing forced degradation studies which indicated susceptibility of the drug under acidic and neutral hydrolyti...