The acronymously named "ESKAPE" pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated emergence, but also due to their ability to "eskape" antibiotic treatment. The evolution of multi-drug resistance in these pathogens alone has greatly outpaced the development of new therapeutics, necessitating an alternati...

Triphenylphosphonium functionalization of a conjugated oligoelectrolyte (COE) with stilbene core improved its spectrum activity to include ESKAPE pathogens and mycobacteria while crucially retaining the membrane-perturbing mode action characteristic COEs. The efficacy lead compound in vivo highlights potential COE molecular platform for designing more effective antibiotics. More information can...

Background: The spread of resistant bacteria has caused serious concern worldwide. multidrug-resistant (MDR) and extensive drug-resistant (XDR) limits the choice antibiotics, making available antibiotics less effective. Objectives: This study aimed to investigate resistance patterns seven global threatening organisms announced by Centers for Disease Control Prevention (CDC) one year in Iran, ca...

ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Enterobacter species) pathogens have characteristic multiple-drug resistance and cause an increasing number of nosocomial infections worldwide. Peptide-based therapeutics to treat ESKAPE infections might be an alternative to conventional antibiotics. Histatin 5 (Hst 5)...