in this study esophageal resection and radiotherapy methods were compared in relation to the patients suffering from esophageal cancer. three hundred and fifty-four patients with squamous cell carcinoma of esophagus who had been hospitalized in the cancer institute of the imam khomeini hospital, tehran, during 1981-1985 were followed up through march 21st, 1987. based on the findings, patients ...

AIMS AND BACKGROUND Esophageal cancer patients with pathologic lymph node involvement generally have a poor prognosis. Many randomized controlled trials have not achieved consistent results similar to those of the RTOG8501 trial, and the long-term survival rate has not increased. The present study aimed to compare the efficacy and toxic side effects of concurrent chemoradiotherapy and radiother...

esophageal cancer is one of the most common malignancies in our country. patients often seek medical advice in advanced and inoperable stages or with cervical esophageal cancer, in which operation is accompanied by sever morbidity. in this conditions many of them cannot tolerate chemo-radiation, or refuse it. therefore radiotherapy is applied as a single modality in palliation of many patients ...

Radiotherapy plays an important role in the treatment for thoracic cancers. Accurate diagnosis is essential to correctly perform curative radiotherapy. Tumor delineation is also important to prevent geographic misses in radiotherapy planning. Currently, planning is based on computed tomography (CT) imaging when radiation oncologists manually contour the tumor, and this practice often induces in...

Esophageal cancer has a high incidence in China (Almhanna et al., 2013; Song et al., 2013), where most patients are diagnosed at middle or advanced stage (Zhao et al., 2007) and not suitable for surgery. Non-surgical treatment of esophageal cancer often relies on radiotherapy and multi-disciplinary comprehensive treatment. For a long time, radiotherapy employs conventional segmentation techniqu...

BACKGROUND Radiation pneumonitis (RP) is a common side reaction in radiotherapy for esophageal cancer. There are few reports about RP in esophageal cancer patients receiving postoperative intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT). This study aims to analyze clinical or dosimetric factors associated with RP, and provides data for radiotherapy planni...

Biomarker identification is crucial for the selection of patients who might benefit from radiotherapy. To explore potential markers for response and prognosis in patients with locally advanced esophageal carcinoma treated with radiotherapy followed by surgery, we evaluated the expression of cell cycle checkpoint-related proteins Chk2, Cdc25C, and Cyclin D1. A total of 56 patients with locally a...

BACKGROUND Carbon-ion radiotherapy has several potential advantages over X-rays. This therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). However, some patients have shown resistance to this treatment. A new effective combined treatment strategy is required for improving the therapeutic effects. Histone deacetylase inhibitors (HDACIs) are new th...

BACKGROUND Self-expanding metal and plastic esophageal stents (SEMS and SEPS, respectively) are used in conjunction with chemoradiation for palliation of malignant dysphagia. To date, the dosimetric effects of stents undergoing proton radiotherapy are not known. STUDY AIM To investigate the proton radiotherapy dose perturbations caused by esophageal stents of varying designs and materials und...

PURPOSE The aim of this study was to evaluate the salvage radiotherapy outcome in patients with local recurrent esophageal cancer after radical radiochemotherapy (RCT). METHODS A total of 114 patients with local recurrent esophageal squamous cell carcinoma after initial radical RCT were retrospectively analyzed. Fifty-five (55) patients belonged to the salvage radiotherapy group (SR group) an...