BACKGROUND Gastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV(1)). OBJECTIVES To identify the patterns of reflux in patients with ESLD and to determine whether antireflux surgery (ARS) positively impacts...

tion of patients with GERD symptoms, including typical symptoms in patients off PPIs, chronic cough and symptoms refractory to PPIs [13–15] . However, few studies have formerly assessed the benefit of impedance-pH monitoring in patients with laryngeal symptoms. Chronic cough related to GERD has been generally attributed to acid reflux. However, acid suppression therapy is not as good as for hea...

OBJECTIVE To determine whether the presence of laryngopharyngeal reflux symptoms is associated with the presence of esophageal adenocarcinoma (EAC). BACKGROUND Most patients diagnosed with EAC have incurable disease at the time of detection. The majority of these patients are unaware of the presence of Barrett's esophagus prior to cancer diagnosis and many do not report typical symptoms of ga...

Gastroesophageal reflux disease (GERD) is a common upper gastrointestinal disease. However, the role of exosomal microRNAs (miRNAs) and esophageal miRNAs in GERD has not been studied. A rat model of acid reflux esophagitis was used to establish a novel diagnosis marker for GERD and examine dynamics of miRNA expression in GERD. Rats were sacrificed 3 (acute phase), 7 (sub-acute phase) and 21 day...

We studied spontaneous gastroesophageal reflux (GER)-induced esophageal distension using ultrasound imaging and its role in the genesis of esophageal symptoms before and during esomeprazole therapy. Ten controls and 10 GER disease (GERD) patients were studied by combined impedance, esophageal pH, manometry, and ultrasonography before and during esomeprazole therapy. Physiological data and sympt...

30 INTRODUCTION Gastroesophageal reflux disease (GERD) is defined as the occurrence of chronic symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. The most common symptom is heartburn, experienced by 10% of the United States population daily and by 40% at least once monthly (1). In addition, it is estimated that more than 40 million people use over...

Gastro-esophageal reflux (GER) is common in infants and children and has a varied clinical presentation: from infants with innocent regurgitation to infants and children with severe esophageal and extra-esophageal complications that define pathological gastro-esophageal reflux disease (GERD). Although the pathophysiology is similar to that of adults, symptoms of GERD in infants and children are...

Introduction: Gastro-esophageal reflux disease (GERD) is present when repeated backflow of gastric contents into the esophagus causes chronic symptoms or damages the esophageal lining. In recent years, the prevalence of GERD has increased and there is a strong correlation between acid reflux and the increasing incidence of esophageal cancer [1]. The gastro-esophageal junction (GEJ) is the key d...

Introduction: Laryngopharyngeal reflux (LPR) is considered an important cause of voice disorder. We aimed to determine the frequency of LPR in patients with voice disorder and the association between Koufman Reflux Symptom Index (RSI), Reflux Finding Score (RFS), gastroesophageal reflux disease (GERD), and proximal acid reflux in these patients. Materials and Methods: We performed a prospective...

Gastro-esophageal reflux disease (GERD) is the result of the acid contents regurgitation back from the stomach into the esophagus. According to the endoscopic findings, GERD can be divided into two main forms: non-erosive (NERD) and erosive reflux esophagitis. The pathogenesis of GERD is associated with the impaired function of the antireflux barrier. Disturbances of the autonomic nervous syste...