At an average age of 70 d, 60 Yorkshire gilts born either in July (Trial 1; n = 30) or August (Trial 2; n = 30) received a diet containing zearalenone for 0 (control), 45 or 90 d. The concentration of zearalenone in diets was 2 ppm for 2 wk and 1.5 ppm for the remainder of the study. Vulval swelling and reddening was evident within 7 d after zearalenone was first fed. Zearalenone consumption ha...

The estrogen receptor was characterized in a new transplantable mammary tumor line (MXT) which was induced by urethan treatment in C57BL x DBAf F, mice. The tumor is a ductal papillary carcinoma that is ovarian dependent. Treat ment of ovariectomized mice with estradiol benzoate results in rapid growth of the tumor. Cytoplasmic and nuclearbound estrogen receptors were measured by the charcoal a...

introduction: estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. alzheimer's disease (ad) is a progressive neurodegenerative disorder that impairs patient memory. the human nucleus basalis of meynert (nbm) is severely affected in alzheimer's disease. so in this study the effect of peripheral (intr...

The estrogen receptor was characterized in a new transplantable mammary tumor line (MXT) which was induced by urethan treatment in C57BL x DBAf F, mice. The tumor is a ductal papillary carcinoma that is ovarian dependent. Treat ment of ovariectomized mice with estradiol benzoate results in rapid growth of the tumor. Cytoplasmic and nuclearbound estrogen receptors were measured by the charcoal a...

The effects of hormonal ablation, estrogen, estrogen-derived cytotoxic agent, and estrogen antagonist therapies used clinically were evaluated on in vitro colony formation, in vivo growth, and lymphatic and pulmonary metastasis of the PAIII tumor. Ventral prostatic and seminal vesicle weights were evaluated in the same animals to assess androgen-related responses. Estradiol, estramustine phosph...

Weanling rats were given 2 mg. of 17-beta-estradiol benzoate at weekly intervals for 4 weeks. Twenty-four hours after each intraperitoneal injection of the estrogen 100 microc. of S(35)-sulfate or 11 microc. of Ca(45) was similarly injected. The animals were sacrificed 24 hours after the last dose of isotopes. An effect of estradiol benzoate on calcium metabolism was deduced from the observatio...

We hypothesized that administration of estradiol benzoate to males and testosterone propionate to female neonatal rat pups alters sex-specific ventilatory responses to aspartic acid with correspondent changes in N-methyl-D-aspartate receptor subunit 1 (NR1) expression determined by Western blot in specific brain regions. One-day-old rat pups received estradiol benzoate, testosterone propionate,...

Estrogens and selective estrogen receptor modulators (SERMs), such as raloxifene (RAL) and tamoxifen (TAM), acutely relax arteries, but the long-term effects of estrogens and SERMs on vascular reactivity in the mesenteric vasculature have not been well defined. In this study, we used an isolated, perfused mesenteric vascular bed technique to investigate the effect of chronic treatment of estrog...

Estrogens, and SERMs such as raloxifene (RAL) and tamoxifen (TAM), acutely relax arteries, but the long term effects of estrogens and SERMs on vascular reactivity in the mesenteric vasculature have not been well-defined. In this study, we used an isolated perfused mesenteric vascular bed technique to investigate the effect of chronic treatment of estrogens and SERMs on vascular reactivity of th...