OBJECTIVE To determine the histopathological effect of estrogen deficiency and hormone replacement treatment on laryngeal tissue in ovariectomized rats. STUDY DESIGN Animal study. SETTING The study was conducted at the animal experiment laboratory of Marmara University School of Medicine, Istanbul, Turkey. SUBJECTS AND METHODS Six-month-old female Wistar albino rats were divided into the ...

OBJECTIVE To assess whether recent epidemiologic evidence supports an association between use of estrogen replacement therapy or hormone replacement therapy and risk of breast cancer. DATA SOURCES The keywords "estrogen," "estrogen replacement therapy," or "hormone replacement therapy," and "breast cancer" or "breast neoplasm," were used to search for articles published from 1975-2000 in MEDL...

PURPOSE OF REVIEW The role of female hormones in estrogen-dependent cancers has been debated for years. This is particularly true of breast cancer. Retrospective, case, and cohort control studies usually have suggested no influence. The Women's Health Initiative study in 2002, a prospective double-blind study, noted an increased risk of breast cancer if estrogen plus progesterone was given. In ...

Hormone replacement therapy involves restoring estrogen (female hormone) to body when levels are diminished. Menopause is the most common cause of low estrogen levels. During menopause ovaries (glands that produce eggs and hormones) stop producing estrogen and body no longer menstruate. Women who have had their ovaries surgically removed have decreased levels of estrogen and experience the same...

INTRODUCTION Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS A total of 24 female Sprague-Dawley rats (200-250 g) were ...

ost of the previous observational studies suggest that estrogen replacement therapy reduces cardiovascular risks,1 but meta-analysis of randomized clinical trials showed increased risk of hormone replacement therapy for cardiovascular events.2 Both hypercoagulability and upregulation of inflammation-sensitive proteins could underline the increased risk of estrogen treatment in coronary artery d...

Gender differences in cardiovascular mortality are well documented and oestrogen replacement therapy in post-menopausal women is associated with improved outcomes from cardiovascular events. Indeed, oestrogen therapy has been shown to restore endothelial function in post-menopausal women and reduce the development of atherosclerotic lesions. Despite extensive evidence on the beneficial effect o...

OBJECTIVES To compare tibolone therapy with four different estrogen replacement therapy protocols, with regard to the effects on plasma lipid profiles. METHODS The plasma lipid levels of 178 postmenopausal women in five different therapy groups were compared with each other as well as their baseline levels with 6-month intervals during 2-year follow-up. Student's t-test, paired t-test and Pea...

Menopause is associated with an increase in blood pressure (BP) and a decrease in physiologic nocturnal BP fall. These factors may play a role in the increased risk of cardiovascular events after menopause. Some studies indicate that transdermal estrogen replacement therapy may help restore the 24-h BP profile, but data on the effect of oral conjugated estrogens are lacking. We compared 24-h am...