Neuroimaging results have raised interest in characterizing hemispheric asymmetries in prefrontal activity during different types of memory retrieval tasks. In this issue, Dobbins et al. and Mitchell et al. report results suggesting that the two hemispheres of the prefrontal cortex may indeed make different contributions to memory retrieval. Here, I discuss these findings within the context of ...

The sixth author’s name is incorrect. The correct name is: The Swedish Addision Registry Study Group. The correct citation is: Mitchell AL, Bøe Wolff A, MacArthur K, Weaver JU, Vaidya B, The Swedish Addison Registry Study Group, et al. (2015) Linkage Analysis in Autoimmune Addison’s Disease: NFATC1 as a Potential Novel Susceptibility Locus. PLoS ONE 10(6): e0123550. doi:10.1371/journal.pone.012...

(Mitchell et al., 2008) showed that it was possible to use a text corpus to learn the value of hypothesized semantic features characterizing the meaning of a concrete noun. The authors also demonstrated that those features could be used to decompose the spatial pattern of fMRI-measured brain activation in response to a stimulus containing that noun and a picture of it. In this paper we introduc...

Methylated purine bases are frequently isolated from marine sponges and ascidians, and their presence is often associated with pronounced biological activity. Rapid dereplication of these compounds in polar extracts of sponges is complicated by dif®culties in their characterization. One such example is 1,3-dimethylisoguanine, (I), which has been described by three different groups but with diff...

Studies have shown that people with dementia receive sub-optimal end-of-life care (McCarthy et al, 1997; Morrison and Siu 2000; Mitchell et al, 2004). The National Institute of Clinical Excellence (NICE) and the National Council for Palliative Care (NCPC) have highlighted the importance of palliative care for people with dementia (NICE 2006; NCPC 2007). This article explores the palliative care...

is presumably because defects in one exosome subunit The eukaryotic cell contains a wide variety of RNA specause a failure to assemble the exosome properly, and cies that are either processed from 39-extended precurthe exosome per se is required for viability. This conclusors or degraded in a 39-to-59 direction. How 39-to-59 sion is supported by the observations that inactivation processing is ...

We present a series of methods for deriving conceptual representations from corpora and investigate the usefulness of the fMRI data and machine learning methodology of Mitchell et al. (2008) as a basis for evaluating the different models. Within this framework, the quality of a semantic model is quantified by its ability to predict the fMRI activation associated with conceptual stimuli. Mitchel...