Archaeal family B polymerases bind tightly to the deaminated bases uracil and hypoxanthine in single-stranded DNA, stalling replication on encountering these pro-mutagenic deoxynucleosides four steps ahead of the primer-template junction. When uracil is specifically bound, the polymerase-DNA complex exists in the editing rather than the polymerization conformation, despite the duplex region of ...

7 we have the regular pure input-buuered switch. In our comparison we consider a Look-ahead scheme with a window of w = 2. We feel that a window of two makes it comparable to the Odd-Even model where contention resolution also consists of two rounds (one for polling the odd and one for polling the even queues). Also, note that in both strategies only one cell can be cleared from a single input ...

The main principle of a look-ahead strategy is to inspect a few steps ahead before taking a decision on the direction to choose. We propose two original look-ahead strategies that differ in the object of inspection. The first method introduces a look-ahead mechanism at a superior level for selecting local-search operators. The second method uses a look-ahead strategy on a lower level in order t...

A systematic method of designing TSC checker for Q class (even code length) of Borden’s code [l] is proposed, where a modular approach is used. In a comparative study, it is found that the proposed method is much better than [2,3] and it has a larger capability than [4,5] in designing the checker. For instance, the 3/12 code in C(12,2) can be identified in one of four ways, corresponding to PT’...

In order to develop reliable applications for parallel machines, programming languages and systems need to provide for flexible parallel programming coordination techniques. Barriers, clocks and phasers constitute promising synchronisation mechanisms, but they exhibit intricate semantics and allow writing programs that can easily deadlock. We present an operational semantics and a type system f...

The “Holy Grail” in molecular imaging of cardiovascular disease is sensitive, specific, economic, and radiationfree detection of atheromata prone to produce thrombotic complications.1,2 In this issue of Circulation Research, Broisat et al3 describe another step on the path toward noninvasive molecular imaging of inflammation in atherosclerotic plaque. Although still unproven, the early detectio...