نتایج جستجو برای: ex vivo lung perfusion evlp
تعداد نتایج: 696289 فیلتر نتایج به سال:
PurposePrimary graft dysfunction (PGD) has a significant impact on both of short- and long-term outcomes. However, no proven measure for treatment after development PGD is available so far, conservative care with extracorporeal membranous oxygenation (ECMO) commonly performed. In this study, we established novel strategy namely vivo lung recovery (IVLR) PGD. IVLR technique applying ex perfusion...
Argon (Ar) is a noble gas with known organoprotective effects in rodents and in vitro models. In a previous study we failed to find a postconditioning effect of Ar during ex vivo lung perfusion (EVLP) on warm-ischemic injury in a porcine model. In this study, we further investigated a prolonged exposure to Ar to decrease cold ischemia-reperfusion injury after lung transplantation in a porcine m...
We developed a protocol to procure lungs from uncontrolled donors after circulatory determination of death (NCT02061462). Subjects with cardiovascular collapse, treated on scene by a resuscitation team and transferred to the emergency room, are considered potential donors once declared dead. Exclusion criteria include unwitnessed collapse, no-flow period of >15 min and low flow >60 min. After d...
BackgroundAlthough it is intense in health care resources, by facilitating assessment and reconditioning, ex vivo lung perfusion (EVLP) has the potential to expand donor pool improve transplant outcomes. However, inclusion criteria used EVLP trials have not been validated.MethodsThis retrospective study from 2014 2018 reviewed our local state-based donation organization records as well subseque...
Central MessageAdaptions of current EVLP protocols are needed to be able perfuse donor lungs for 24 hours and longer.See Article page 1963. Adaptions longer. See A great potential ex vivo lung perfusion (EVLP) lies in reconditioning grafts an unacceptable quality so that they can used transplantation. In this regard, several approaches have been described experimental studies, including the tre...
BACKGROUND Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflammatory and immunomodulatory role of human mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) to attenuate lung IR injury and improve of ex-vivo lung p...
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