BACKGROUND & OBJECTIVE Drugs like famotidine, omeprazole and sucralfate which have been reported to promote the healing of gastric ulcers, may have the same effect on cutaneous wounds. Due to paucity of information in this regard, the present study was planned to investigate the effect of these drugs on resutured incision, excision and dead space wounds in Wistar rats. METHODS Resutured incis...

Using incision, excision and dead space wound models in rats, a study was conducted on the effect of histamine on wound healing. Exogenous histamine given either ip or locally was without any effect. Semicarbazide as (histamine synthesis inhibitor) suppressed healing process (breaking strength of skin incision wound), decreased breaking strength and hydroxyproline content of granulation tissue ...

Wound healing activity of methanolic extract of leaves of Alternanthera brasiliana Kuntz was studied by excision and incision wound model (in vivo) in Sprague Dawley rats and by Chorioallantoic membrane (CAM) model (In vitro) in 9-day-old embryonated chicken eggs. In excision wound model, compared to the control group, per cent contraction of wound was significantly higher in A. brasiliana (5% ...

Leaf extract of guava (Psidium guajava Linn.) has been reported to promote wound healing in traditional medicine but there is paucity of information in literature regarding similar activity of fruit extract. Therefore, the present study was planned to investigate the influence of leaf and fruit extract of Psidium guajava Linn. on re-sutured incision, excision, and dead space wounds in male Wist...

Background: Plants and their phytochemicals have immense potential for the management of different types of wound. Salvia multicaulis Vahl. is an evergreen shrub species, which traditionally used as a wound healing agent. Objective: The aim of the present study is to evaluate phytochemicals and wound healing activity of S. multicaulis in an excision wound model. Methods: Preliminary phytochemic...

To screen the wound healing activity of different extracts of Allium cepa L. in excision, incision and dead space wound models in albino rats. The tubers of Allium cepa L. (Family Liliaceae) were exhaustively defatted with petroleum ether (40-60C) and the marc was subjected to continuous extraction with solvent ether, chloroform, alcohol and chloroform water I.P. All the extracts were tested fo...

The different extracts of the bark of Tecoma stans Linn. (Bignoniaceae) was evaluated for its wound healing potential in two different types of wound models in albino rats viz., incision and excision. The different extracts of Tecoma stans are obtained by successive soxhlet extraction with petroleum ether, chloroform and methanol. The methanolic extract showed significant increase in wound cont...

Achillea species are widely used for diarrhea, abdominal pain, stomachache and healing of wounds in folk medicine. To evaluate the wound healing activity of the plant, extracts were prepared with different solvents; hexane, chloroform, ethyl acetate and methanol, respectively from the roots of Achillea biebersteinii. Linear incision by using tensiometer and circular excision wound models were e...

The methanol extract of Alternanthera brasiliana Kuntze (Family: Amaranthaceae) leaf was investigated for its wound healing effect by excision wound model (in vivo) in aged Sprague Dawley rats. In excision wound model, compared to the control group, percent contraction of wound was significantly (P < 0.01) higher in A. brasiliana-treated group (5% w/w ointment). The collagen, elastin, and hydro...

Solanum xanthocarpum Schrad. & Wendl. (Family-Solanaceae), commonly known as Yellow-Berried Nightshade, fruits are used traditionally in the folklore for treatment of various kinds of wounds. The present study was undertaken to verify the effects of its fruits on experimentally induced excision and incision wound models in Sprague Dowlay rats. Aloe vera Linn. was used as standard wound healing ...