Accurate, efficient measurement of disease status has become a key issue in MS clinical practice and research. Despite some perceived problems, the Expanded Disability Status Scale (EDSS) remains the most widely used comprehensive measure of impairment. There is also a place for more restricted scales of impairment which focus on some aspects of neurological function in more detail than the EDS...

Tecfidera has been shown to be of benefit in relapsing multiple sclerosis in two Phase III clinical trials. In the DEFINE trial, the medication produced a 49% reduction in the proportion of people who experienced relapses over 2 years, and had a similar significant impact on disease activity detected on MRI., This resulted in a 38% reduction in the risk of confirmed progression of disability as...

background: there is a known inverse association between solar radiation and the prevalence of multiple sclerosis (ms). some studies have investigated the link between vitamin d and ms. the aim of this study was to investigate the possible association between serum 25(oh) vitamin d3 concentration and the severity of disease in iranian patients with ms. methods: patients with relapsing-remitting...

There were 21 patients with rapidly progressive multiple sclerosis (MS) treated on a phase 1/2 study of intense immune suppressive therapy and autologous hematopoietic stem cell (HSC) support with no 1-year mortality. Following transplantation, one patient had a confirmed acute attack of MS. Neurologic progression defined by the expanded disability status scale (EDSS) did not increase in disabi...

Aims: Active and progressive resistance training has a key role in functional recovery and quality of life in patients with MS. Therefore, this study aimed to investigate the effects of isotonic and isometric exercises on balance and ability in patients with MS. Materials & Methods: In this randomized clinical trial, 60 patients with MS admitted to MS Special Diseases Center in Yasuj during 20...

The objective of this study was to evaluate relationships between subjective and objective measures of balance in multiple sclerosis (MS). In 54 subjects with MS, balance was measured objectively with the Sensory Organization Test (SOT) using dynamic posturography and subjectively with the Activities-specific Balance Confidence (ABC) Scale and the Falls Efficacy Scale-International (FES-I). MS-...

Cognitive and emotional capabilities were evaluated in 73 female patients with stable relapsing-remitting definite, and/or laboratory-supported multiple sclerosis (MS) and were compared with 32 matched healthy controls. Patients were categorized according to their score in the expanded disability status scale (EDSS) to either no (EDSS 0, n = 33) or few clinical signs (EDSS 1-2, n = 40) of MS wi...

OBJECTIVE To better characterize the relationship between cerebral white matter lesion load (CWM-LL) and clinical disability by (1) covering the entire range of the Kurtzke Expanded Disability Status Scale (EDSS), (2) minimizing nonbiological sources of variability, and (3) increasing pathologic specificity by studying CWM lesions that are hypointense on T1-weighted magnetic resonance imaging. ...