OBJECTIVES To assess the magnitude of the correlations between disability and composite MRI scores in patients with MS. METHODS T2- and T1-weighted MRI, magnetization transfer imaging, diffusion tensor imaging, and MRS imaging scans of the brain from 23 patients with MS were obtained. T2 lesion volume, T1 lesion volume, brain magnetization transfer ratio, average brain diffusivity (D), and br...

Introduction: The purpose of the study is to investigate correlation between the expanded disability status scale, depression, quality of life (QoL) and age as well as to investigate the impact of the interferon beta-1b in the QoL of MS patients and its possible depressogenic effect. Material and methods: This prospective study included 70 randomly selected patients with MS treated in the clini...

BACKGROUND Low-contrast visual acuity (LCVA), a sensitive measure of visual function in multiple sclerosis (MS), demonstrated treatment effects as a secondary outcome measure in the Phase 3 trial of natalizumab, AFFIRM. In these posttrial analyses, we studied the relation of visual function to quality of life (QOL), magnetic resonance imaging (MRI) measures, and Expanded Disability Status Scale...

Among other symptoms, multiple sclerosis can also produce symptoms of affective and cognitive disorders. The majority of patients have certain cognitive dysfunctions, and the' most common affective disorder is reactive depression. The aim of the study was to determine the correlation of the Mini-Mental State (MMS) and Beck Depression Inventory (BDI) scale scores with the Expanded Disability Sta...

BACKGROUND The course of multiple sclerosis (MS) has been studied in several cohorts; however, results have varied significantly. OBJECTIVE To describe the clinical course of MS in a nationwide cohort of patients. METHOD Data from the Swedish MS register (SMSreg) were used to estimate the median time to the sustained Expanded Disability Status Scale (EDSS) scores 3.0, 4.0 and 6.0, onset of ...

BACKGROUND Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples. OBJECTIVE To explore the correlation of MRI-derived measures with EDSS through ...

OBJECTIVE To analyse the value of the INTERMED, a screening instrument to assess case complexity, compared with the Expanded Disability Status Scale (EDSS) and the Guy's Neurological Disability Scale (GNDS) to identify multiple sclerosis (MS) patients in need of multidisciplinary treatment. METHODS One hundred MS patients underwent INTERMED, EDSS, and GNDS examinations. Patient care needs wer...

Sustained progression on the expanded disability status scale (EDSS) is a common outcome measure of disease progression in clinical studies of MS. Unfortunately, this outcome may not accurately measure long-term and irreversible disease progression. To assess the performance of definitions of sustained progression, patients with relapsing-remitting MS (RRMS) or a clinically isolated syndrome wi...

background: multiple sclerosis is a common and chronic neurologic disorder. this disorder imposes physical, economic, and psychosocial burden on individuals, their families and society. this study aims to analyze the costs of multiple sclerosis disease based on the severity of disability. methods: we performed a cross‑sectional cost of illness study. this study was conducted in 332 patients of ...

UNLABELLED The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categor...