Classical cadherin adhesion molecules are key determinants of cell-cell recognition during development and in post-embryonic life. A decisive step in productive cadherin-based recognition is the conversion of nascent adhesions into stable zones of contact. It is increasingly clear that such contact zone extension entails active cooperation between cadherin adhesion and the force-generating capa...

Threshold models try to explain the consequences of social influence like the spread of fads and opinions. Along with models of epidemics, they constitute a major theoretical framework of social spreading processes. In threshold models on static networks, an individual changes her state if a certain fraction of her neighbors has done the same. When there are strong correlations in the temporal ...

In this paper, we present a comprehensive, yet simple, extension to the existing systems used for Digital Contact Tracing in Covid-19 pandemic. The extension, called BubbleAntiCovid19 (BAC19), enables those systems, regardless of their underlying protocol, enhance sets traced contacts and improve global fight against pandemic during phase opening borders enabling more traveling. BAC19 is Struct...

objective: interceptive contacts in complete denture cause some side effects. to our knowledge, however, no comprehensive reports exist on the prevalence of interceptive contacts after complete denture placement. the aim of the present study was to investigate the prevalence of interceptive contacts in inserted complete dentures and its associated factors. materials and methods: this cross sect...

Close contacts are the predominant type of cell-substratum adhesion in rapidly moving cells yet little is known about their composition and dynamics. To address these issues we have attempted to identify the molecular components of close contacts formed in rapidly moving fish epithelial keratocytes. In addition we have utilized the simple shape of keratocytes to explore the relationship between...

Long non-coding RNAs (lncRNAs) are prominently associated with chromosomes in an ever-increasing diversity of roles. To provide further insight into the potential nature of these associations, we have explored, for the first time, the interaction of long single-stranded (ss) RNAs with cognate homologous double-stranded (ds) DNA in vitro Using magnetic tweezers, we measured the effects of ssRNA ...

FKBP38 regulates apoptosis through unique interactions with multiple regulators including Bcl-2. Interestingly, the peptidylprolyl isomerase activity of FKBP38 is only detectable when it binds to calcium-saturated calmodulin (CaM/Ca(2+)). This, in turn, permits the formation of a complex with Bcl-2. FKBP38 thereby provides an important link between isomerase activity and apoptotic pathways. Her...

In the process of neuronal wiring, axons derived from the same functional group typically extend together, resulting in fascicle formation. How these axons communicate with one another remains largely unknown. Here, we show that protocadherin-17 (Pcdh17) supports this group extension by recruiting actin polymerization regulators to interaxonal contact sites. Pcdh17 is expressed by a subset of a...

1100 160 No. of cholera marked the extension of the seventh cholera pandemic into Peninsular Malaysia and the beginning of a long period of endemicity of El Tor cholera in Peninsular Malaysia. From 1963 to 1978, cholera had been reported almost yearly in Peninsular Malaysia (Figure 1) with major In the outbreak of cholera in Perak in 1978, a study on 179 cholera patients (cases) from 8 health d...