The PB1-F2 protein of influenza A virus has been considered a virulence factor, but its function in inducing apoptosis may be of disadvantage to viral replication. Host mechanisms to regulate PB1-F2-induced apoptosis remain unknown. We generated a PB1-F2-deficient avian influenza virus (AIV) H9N2 and found that the mutant virus replicated less efficiently in human lung epithelial cells. The PB1...

We define a self-map Pal : F2 → F2 of the free group on two generators a, b, using automorphisms of F2 that form a group isomorphic to the braid group B3. The map Pal restricts to de Luca’s right iterated palindromic closure on the submonoid generated by a, b. We show that Pal is continuous for the profinite topology on F2; it is the unique continuous extension of de Luca’s right iterated palin...

We present a new variant of the block Lanczos algorithm for finding vectors in the kernel of a symmetric matrix over F2. Our algorithm is at least as efficient as that of Peter Montgomery [6], while the sequence of matrices Wi constructed here have different algebraic properties that may be useful in eventually providing a provable upper bound on the time required to solve this problem. Namely,...

We describe algorithms for polynomial factorization over the binary field F2, and their implementation. They allow polynomials of degree up to 250 000 to be factored in about one day of CPU time, distributing the work on two processors.

The ability for a host to recognize infection is critical for virus clearance and often begins with induction of inflammation. The PB1-F2 of pathogenic influenza A viruses (IAV) contributes to the pathophysiology of infection, although the mechanism for this is unclear. The NLRP3-inflammasome has been implicated in IAV pathogenesis, but whether IAV virulence proteins can be activators of the co...

The aim of the present study was to identify what influences the short half-life of the influenza A virus PB1-F2 protein and whether a prolonged half-life affects the properties of this molecule. We hypothesized that the short half-life of PB1-F2 could conceal the phenotype of the protein. Because proteasome degradation might be involved in PB1-F2 degradation, we focused on ubiquitination, a co...