BACKGROUND The efficacy of many preparations for topical use in herpes infections have remained rather disappointing. The development of new antiviral drugs, especially herbal preparations, thus remains desirable. In a screening study with plant extracts, a rhubarb root extract and a sage extract showed a promising activity. OBJECTIVE The efficacy of a combined topical preparation with rhubar...

background: the aim of this study was to examine the renoprotective effect of hydro alcoholic sage (salvia officinalis: so) leaves extract against gentamicin-induced nephrotoxicity in rats. methods: in this experimental study forty male sprague dawley rats weighing 200-300 g were randomly divided into 5 groups; (1) the rats without treatment (control), (2) intraperitoneally injected with normal...

UNLABELLED Serial analysis of gene expression (SAGE) is a powerful quantification technique for gene expression data. The huge amount of tag data in SAGE libraries of samples is difficult to analyze with current SAGE analysis tools. Data is often not provided in a biologically significant way for cross-analysis and -comparison, thus limiting its application. Hence, an integrated software platfo...

The SAGE (serial analysis of gene expression) method is sensitive at detecting the lower abundance transcripts. More than a third of human SAGE tags identified are novel representing the low abundance unknown transcripts. Using the GLGI method (generation of longer 3’ EST from SAGE tag for gene identification), we converted 1,009 low-copy, human X chromosomespecific SAGE tags into the 3’ ESTs. ...

We have developed a technique called the generation of longer cDNA fragments from serial analysis of gene expression (SAGE) tags for gene identification (GLGI), to convert SAGE tags of 10 bases into their corresponding 3' cDNA fragments covering hundred bases. A primer containing the 10-base SAGE tag is used as the sense primer, and a single base anchored oligo(dT) primer is used as an antisens...

BACKGROUND Although Salvia sclarea (clary sage) is widely used in aromatherapy and has antioxidant and antimicrobial properties, its mechanisms of action remain poorly understood. We therefore assessed whether clary sage is effective in treating endothelial dysfunction induced by chronic immobilization stress in rats. METHODS Rats were intraperitoneally injected with almond oil, clary sage oi...

Coyotes (Canis latrans) are lethally controlled throughout the range of Greater Sage-Grouse (Centrocercus urophasianus) and it has been suggested that such control may benefit sage-grouse. However, the perceived benefits of control are based on the direct effects of coyotes on sage-grouse and largely ignore potential indirect interactions. Here, we summarize some of the evidence for direct effe...

BACKGROUND To facilitate in the identification of gene products important in regulating renal glomerular structure and function, we have produced an annotated transcriptome database for normal human glomeruli using the SAGE approach. DESCRIPTION The database contains 22,907 unique SAGE tag sequences, with a total tag count of 48,905. For each SAGE tag, the ratio of its frequency in glomeruli ...