Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of intracellular signaling adaptors that associate with the cytoplasmic tails diverse range lymphocyte receptors, including members TNFR superfamily, Toll-like (TLR)/interleukin-1 (IL-1) and IL-6 major targets for therapeutic intervention inflammatory diseases. TRAF5 is one seven TRAF highly expressed by B- T-lymphocy...