The polymorphism G20210A in the 3' untranslated region of the prothrombin gene is associated with an increased level of factor II activity and confers a twofold to fivefold increase in the risk for venous thromboembolism. Among Caucasian populations, the prevalence of factor II G20210A heterozygotes is 1% to 6%, whereas in non-Caucasian populations it is very rare or absent. The aim of the pres...

cerebral vein thrombosis (cvt) is an infrequent condition with a large variety of causes that can lead to serious disabilities. however, in 20% to 35% of cases, no cause is found. in this study we evaluated the hereditary (p & c proteins, antithrombin, mutation of prothrombin g20210a and factor v leiden), other risk factors (hyperhomocycteinemia, factor viii, acl-ab, apl-ab, and ocp) and clinic...

BACKGROUND Intrauterine growth restriction (IUGR) is a major cause of fetal morbidity and mortality during pregnancy. The role of mutation in the factor V gene, prothrombin gene, MTHFR gene, as risk factors for intrauterine growth restriction during pregnancy, is not very well known so far. MATERIALS AND METHODS This is a retrospective study of 151 pregnant women with a history of complicated...

recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. it has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. thrombophilia is an important predisposition to blood clot formation and is cons...

A. 510(k) Number: k093974 B. Purpose for Submission: New Device C. Measurand: Factor II (FII) (Prothrombin) Factor V (FV) Leiden 5, 10 methylenetetrahydrofolate reductase (MTHFR) D. Type of Test: Qualitative genotyping test for single nucleotide polymorphism detection E. Applicant: Osmetech Molecular Diagnostics F. Proprietary and Established Names: eSensor® Thrombophilia Risk Test eSensor® FII...

BACKGROUND Emerging perioperative genomics may influence the direction of risk assessment and surgical strategies in cardiac surgery. The aim of this study was to investigate whether single nucleotide polymorphisms (SNP) affect the clinical presentation and predispose to increased risk for postoperative adverse events in patients undergoing coronary artery bypass grafting surgery (CABG). METH...

kidney disease who started peritoneal dialysis in 2000. Four years later, the patient received a cadaver donor transplant from a 52-year-old woman. Surgery was performed without technical difficulties and good initial graft perfusion was observed. An immunosuppressive regimen consisting of tacrolimus, mycophenolate mofetil and steroids was initiated. The post-operative course showed persistent ...

BACKGROUND A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. METHODS AND RESULTS In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant i...