OBJECTIVE To determine whether whole-brain, event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. METHODS Sixty-nine cognitively asymptomatic adults were divided into 3 groups (n = 23 each) based on AD risk: 1) no...

Although a family history (FH) of hypertension is a risk factor for the development of hypertension, only a few studies have investigated in detail the impact of individual components of an FH on incident hypertension. We investigated the impact of individual components and their combinations on the presence or development of hypertension considering obesity, smoking habits, physical activity, ...

BACKGROUND Individuals who have a family history (FH) of Alzheimer disease (AD) or who carry the apolipoprotein E epsilon4 allele are at increased risk for developing AD. Abnormalities in brain event-related potentials (ERPs) have been observed in patients diagnosed as having AD. OBJECTIVE To determine whether groups of nonsymptomatic, middle-aged individuals at increased risk for AD exhibite...

BACKGROUND Individuals with a family history of alcoholism (FH+) are at enhanced risk of developing alcohol or other substance use disorders relative to those with no family history (FH-). Alcoholics and FH+ subjects have greater interference scores on the Stroop color-word task, suggesting these impairments may be a component of the cognitive phenotype of at-risk individuals. METHODS In this...

A positive family history (FH) raises the risk for late-onset Alzheimer's disease though, other than the known risk conferred by apolipoprotein ε4 (ApoE4), much of the genetic variance remains unexplained. We examined the effect of family history on longitudinal regional brain atrophy rates in 184 subjects (42% FH+, mean age 79.9) with mild cognitive impairment (MCI) enrolled in a national biom...

The aim of the study was to examine the profiles of children with a family history (FH+) of language-learning impairments (LLI) and a control group of children with no reported family history of LLI (FH-) and identify which language constructs (receptive or expressive) and which ages (2 or 3 years) are related to expressive and receptive language abilities, phonological awareness, and reading a...

BACKGROUND We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1(st) degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH-) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibili...

Introduction-This an in-depth investigation of the relationship between some new aspects of positive family history (FH) of coronary artery disease (CAD) and other risk factors related to CAD in patients with acute myocardial infarction (AMI). MethodThe data of 200 patients with AMI and positive FH of CAD (FH Pos.)as case groupand 200 AMI patients without FH of CAD -as control group(FH Neg.) we...

Background: Overweight children and adolescents with family history of chronic diseases are at greater risk to develop health problems compared to their normal-weight counterparts. The aim of this study was to assess the obesity and family history of non-communicable diseases among adolescents living in city of Karachi, Pakistan. Methods: A descriptive cross sectional study was conducted among ...

This study investigated, in normotensive adolescents, three accepted risk factors for essential hypertension (EH): stress, dietary salt, and parental history (genetic risk). The cardiovascular response to mental stress was evaluated before and after salt loading in eight subjects without, and in seven with, a family history (FH) of EH. The effect of salt loading on the FH positive group was to ...